Evidence map›Paper›PMID 25535912›Full record

ArticleDevelopmental cell2014

Unleashing mesenchymal chemotaxis.

Rocío Aguilar-Cuenca, Miguel Vicente-Manzanares

Abstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Rocío Aguilar-CuencaUniversidad Autónoma de Madrid School of Medicine and Instituto de Investigación Sanitaria- Hospital Universitario de la Princesa (IIS-IP), Diego de León 62, 28006 Madrid, Spain.
Miguel Vicente-ManzanaresUniversidad Autónoma de Madrid School of Medicine and Instituto de Investigación Sanitaria- Hospital Universitario de la Princesa (IIS-IP), Diego de León 62, 28006 Madrid, Spain. Electronic address: miguel.vicente@uam.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of Developmental Cell, Asokan and colleagues (2014) report that the phospholipase Cγ (PLCγ)-diacyl glycerol (DAG) protein kinase Cα (PKCα) signaling axis inhibits actomyosin bundling. This preferentially occurs at the leading edge of chemotactic mesenchymal cells via noncanonical phosphorylation of the regulatory light chain (RLC) of nonmuscle myosin II.

Indexed as

AnimalsChemotaxisHumansMesodermMyosin Type IIPhospholipase C gammaProtein Kinase C-alphaMyosin Type IIPhospholipase C gammaProtein Kinase C-alpha

Identifiers

PMID25535912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.