ArticleBrain, behavior, and immunity2015
Cytokine polymorphisms and plasma levels are associated with sleep onset insomnia in adults living with HIV/AIDS.
Article in Brain, behavior, and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- IL1B-centered immune dysregulation involving IL7R, CCR7, ITGB2 and IRF1 across insomnia and inflammatory bowel disease.Frontiers in immunology · 2026Article
- UPLC-Q-TOF-MS/MS Combined with Network Pharmacology, Molecular Docking, and Animal Verification Reveals the Mechanism of Insomnia Treatment by Shen Qi Wu Wei Zi Capsules.Combinatorial chemistry & high throughput screening · 2024Article
- Prevalence of Risk Factors Associated With Poor Quality of Sleep in People Living with HIV and the Correlation between Quality of Sleep and Cd4+ T Lymphocyte Reconstitution: A Cross-Sectional Study from Turkey.Current HIV research · 2024Article
- Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV).Journal of pineal research · 2023Article
- Article
- Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study.PloS one · 2021Article
- The Interplay Between Neuroinfections, the Immune System and Neurological Disorders: A Focus on Africa.Frontiers in immunology · 2021Review
- Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data From the Veterans Aging Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Differential relationships between cannabis consumption and sleep health as a function of HIV status.Drug and alcohol dependence · 2018Article
- Association between IL-1 gene polymorphisms and tuberculosis susceptibility in the Chinese Tibetan population.International journal of clinical and experimental pathology · 2018Article
- Cytokine Gene Polymorphisms Associated With Symptom Clusters in Oncology Patients Undergoing Radiation Therapy.Journal of pain and symptom management · 2017Article
- Cytokine polymorphisms are associated with daytime napping in adults living with HIV.Sleep medicine · 2017Article
- Teriflunomide and monomethylfumarate target HIV-induced neuroinflammation and neurotoxicity.Journal of neuroinflammation · 2017Article
- Sleep and immunity: A growing field with clinical impact.Brain, behavior, and immunity · 2015Article
- Personalized- and one- medicine: bioinformatics foundation in health and its economic feasibility.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Sex-Based Differences in Plasma Cytokine Concentrations and Sleep Disturbance Relationships Among People Living With HIV.The Journal of the Association of Nurses in AIDS Care : JANACArticle
- CD4+ T Cell Count, Sleep, Depression, and Anxiety in People Living With HIV: A Growth Curve Mixture Modeling.The Journal of the Association of Nurses in AIDS Care : JANACArticle
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Sleep disturbance has been associated with inflammation and cytokine activity, and we previously described genetic associations between cytokine polymorphisms and sleep maintenance and duration among adults with HIV/AIDS. Although sleep onset insomnia (SOI) is also a commonly reported sleep problem, associations between cytokine biomarkers and SOI have not been adequately studied. The purpose of this study was to describe SOI in relation to cytokine plasma concentrations and gene polymorphisms in a convenience sample of 307 adults (212 men, 72 women, and 23 transgender) living with HIV/AIDS. Based on the Pittsburgh Sleep Quality Index item that asks the time it usually took to fall asleep in the past month, participants were categorized as either >30min to fall asleep (n=70, 23%) or 30min or less to fall asleep (n=237). Plasma cytokines were analyzed, and genotyping was conducted for 15 candidate genes involved in cytokine signaling: interferon-gamma (IFNG), IFNG receptor 1 (IFNGR1), interleukins (IL1R2, IL2, IL4, IL6, IL8, IL10, IL13, IL17A), nuclear factor of kappa light polypeptide gene enhancer in B cells (NFKB1 and NFKB2), and tumor necrosis factor alpha (TNFA). Demographic and clinical variables were evaluated as potential covariates. After adjusting for genomic estimates of ancestry, self-reported race/ethnicity and viral load, SOI was associated with higher IL-13 plasma levels and with six single nucleotide polymorphisms (SNPs): IL1B rs1143642 and rs1143623, IL6 rs4719714, IL13 rs1295686, NFKB1 rs4648110, and TNFA rs2857602. In addition, the IL1B rs1143642 polymorphism was associated with plasma levels of IL-1β in adjusted analyses. This study strengthens the evidence for an association between inflammation and sleep disturbance, particularly self-report of habitual SOI. In this chronic illness population, the cytokine polymorphisms associated with SOI provide direction for future personalized medicine intervention research.
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