ArticleeLife2014
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 366 papers.
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Who cites it
366 citing papers in PubMed.
- Article
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- Creating true and false memories from forgotten information in Drosophila.Nature neuroscience · 2026Article
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- Hunger states modulate aggression via opposing dopamine pathways.Nature communications · 2026Article
- An octopamine-glutamate cotransmitting neuron gates aggressive escalation through layered inhibition inScience advances · 2026Article
- Bioamine disruption leads to memory deficits in the whip spider, Phrynus marginemaculatus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- A highly sensitive genetically encoded red cAMP sensor for multiplex imaging in vivo.Nature communications · 2026Article
- Octopamine regulates neural circuits in the mushroom body and central complex, influencing sleep and arousal.iScience · 2026Article
- Autobehaver: An AI-Based Pipeline for Animal Behavior Analysis.bioRxiv : the preprint server for biology · 2026Article
- Spatial and morphological organization of mitochondria in neurons across a connectome.Science (New York, N.Y.) · 2026Article
- Divergent sensory transcriptomic profiles in positive and negative learning in Bicyclus Anynana butterflies.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- A pair of interneurons that confer positive real-time valence to sweet sensation in Drosophila.Current biology : CB · 2026Article
- Neural circuits regulating social dominance implement a strategy predicted by evolutionary game theory.bioRxiv : the preprint server for biology · 2026Article
- A J-domain protein enhances memory by promoting physiological amyloid formation inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Convergence-divergence circuits for multimodal integration of innate and learned opponent valences.Frontiers in systems neuroscience · 2026Article
- Dual roles ofiScience · 2025Article
- Review
- A switch in arousal circuit architecture shapes sleep across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- From perception to valence: a pair of interneurons that assign positive valence to sweet sensation inbioRxiv : the preprint server for biology · 2025Article
306 more citing papers are in PubMed but not listed here.
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21 authors.
Funding
Abstract
Animals discriminate stimuli, learn their predictive value and use this knowledge to modify their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes. Sensory stimuli are sparsely represented by ∼2000 Kenyon cells, which converge onto 34 output neurons (MBONs) of 21 types. We studied the role of MBONs in several associative learning tasks and in sleep regulation, revealing the extent to which information flow is segregated into distinct channels and suggesting possible roles for the multi-layered MBON network. We also show that optogenetic activation of MBONs can, depending on cell type, induce repulsion or attraction in flies. The behavioral effects of MBON perturbation are combinatorial, suggesting that the MBON ensemble collectively represents valence. We propose that local, stimulus-specific dopaminergic modulation selectively alters the balance within the MBON network for those stimuli. Our results suggest that valence encoded by the MBON ensemble biases memory-based action selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.