Evidence map›Paper›PMID 25535793›Full record

ArticleeLife2014

The neuronal architecture of the mushroom body provides a logic for associative learning.

Yoshinori Aso, Daisuke Hattori, Yang Yu, Rebecca M Johnston, Nirmala A Iyer, Teri-T B Ngo, Heather Dionne, L F Abbott, Richard Axel, Hiromu Tanimoto and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 560 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
560citing papers in PubMed, 1 pooled it
24.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

560 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,138 citations in OpenAlex.

  1. Pooled it
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  13. Critical period plasticity enables credit assignment.bioRxiv : the preprint server for biology · 2026
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500 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Yoshinori AsoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Daisuke HattoriHoward Hughes Medical Institute, Columbia University, New York, United States.
Yang YuJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Rebecca M JohnstonJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Nirmala A IyerJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Teri-T B NgoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Heather DionneJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
L F AbbottDepartment of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, United States.
Richard AxelHoward Hughes Medical Institute, Columbia University, New York, United States.
Hiromu TanimotoTohuku University Graduate School of Life Sciences, Sendai, Japan.
Gerald M RubinJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Howard Hughes Medical Institute · USJanelia Research Campus · USColumbia University · USMax Planck Institute of Neurobiology · DE

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each of the 21 MB output neuron (MBON) types elaborates segregated dendritic arbors along the parallel axons of ∼2000 Kenyon cells, forming 15 compartments that collectively tile the MB lobes. MBON axons project to five discrete neuropils outside of the MB and three MBON types form a feedforward network in the lobes. Each of the 20 dopaminergic neuron (DAN) types projects axons to one, or at most two, of the MBON compartments. Convergence of DAN axons on compartmentalized Kenyon cell-MBON synapses creates a highly ordered unit that can support learning to impose valence on sensory representations. The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory.

Indexed as

Association LearningLogicAnimalsBrainCell CompartmentationCell ShapeDendritesDopaminergic NeuronsDrosophila melanogasterGreen Fluorescent ProteinsModels, NeurologicalMushroom BodiesNeurotransmitter AgentsOlfactory PathwaysSensory Receptor CellsSmellGreen Fluorescent ProteinsNeurotransmitter Agentsassociative memoryD. melanogasterdopaminemushroom bodyneuronal circuitsneuroscienceolfactory learningplasticity

Identifiers

PMID25535793
PMCPMC4273437
OpenAlexW2117794907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.