Evidence map›Paper›PMID 25535753›Full record

ArticleAIDS (London, England)2015

Trends in HIV acquisition, risk factors and prevention policies among youth in Uganda, 1999-2011.

John S Santelli, Zoe R Edelstein, Ying Wei, Sanyukta Mathur, Xiaoyu Song, Ashley Schuyler, Fred Nalugoda, Tom Lutalo, Ron Gray, Maria Wawer and 1 more

Open access · greenAbstract read
In one paragraph

Article in AIDS (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  7. Article
  8. Article
  9. Narrating the Transition to Adulthood for Youth in Uganda: Leaving School, Mobility, Risky Occupations, and HIV.Health education & behavior : the official publication of the Society for Public Health Education · 2019
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. HIV Prevention Efforts and Incidence of HIV in Uganda.The New England journal of medicine · 2017
    Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

John S SantelliaColumbia University Mailman School of Public Health bHIV Center for Clinical and Behavioral Studies, Columbia University, New York, New York, USA cRakai Health Sciences Program, Uganda Virus Research Institute, Entebbe, Uganda dBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Zoe R Edelstein
Ying Wei
Sanyukta Mathur
Xiaoyu Song
Ashley Schuyler
Fred Nalugoda
Tom Lutalo
Ron Gray
Maria Wawer
David Serwadda
Columbia University · USRakai Health Sciences Program · UGJohns Hopkins University · USNew York Psychoanalytic Society and Institute · USUganda Virus Research Institute · UG

Funding

Rakai Adolescent Project (RAP)R01HD061092 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SANTELLI, JOHN S. · 2009 to 2013
$2.3M
NICHD NIH HHS R01 HD061092
6 · The paper itself

Abstract

objectiveThe objective of this study is to understand how trends in HIV acquisition among youth can be influenced by change in HIV risk factors, social factors and prevention and treatment programmes.

designTrends in HIV incidence (per 1000 person-years), by sex and age group, were estimated using data from youth (15-24 years: n = 22,164) in the Rakai Community Cohort Study. Trends in HIV incidence were compared with trends in previously identified HIV risk factors, social factors and programmes.

methodsPoisson and linear regression were used to test for statistical significance and decomposition was used to calculate attribution of risk factors to HIV incidence.

resultsSubstantial declines between 1999 and 2011 occurred in sexual experience, multiple partners and sexual concurrency among adolescents and young adults. HIV acquisition declined substantially (86%, P = 0.006) among adolescent women (15-19 years) but not among men or young adult women. Changes in HIV incidence and risk behaviours coincided with increases in school enrolment, decline in adolescent marriage, availability of antiretroviral therapy (ART) and increases in male medical circumcision (MMC). Much of the decline in HIV incidence among adolescent women (71%) was attributable to reduced sexual experience; the decline in sexual experience was primarily attributable to increasing levels of school enrolment.

conclusionDramatic decreases in HIV incidence occurred among adolescent women in Rakai. Changes in school enrolment and sexual experience were primarily responsible for declining HIV acquisition over time among adolescent women. Given limited improvement among young men and young adult women, the need for effective HIV prevention for young people remains critical.

Indexed as

Health PolicySexual BehaviorAdolescentAdultAntiretroviral Therapy, Highly ActiveCircumcision, MaleFemaleHIV InfectionsHIV SeropositivityHumansIncidenceLongitudinal StudiesMaleMarriageProspective StudiesRisk Factors

Identifiers

PMID25535753
PMCPMC6668715
OpenAlexW2034140914

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.