Evidence map›Paper›PMID 25535752›Full record

ArticleAIDS (London, England)2015

The impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to bacille Calmette-Guérin vaccination.

Christine E Jones, Anneke C Hesseling, Nontobeko G Tena-Coki, Thomas J Scriba, Novel N Chegou, Martin Kidd, Robert J Wilkinson, Beate Kampmann

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. Impact ofFrontiers in immunology · 2024
    Article
  3. Science advances · 2023
    Article
  4. Review
  5. What's Old and New in Tuberculosis Vaccines for Children.Journal of the Pediatric Infectious Diseases Society · 2022
    Article
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Article
  11. Maternal LatentFrontiers in immunology · 2020
    Observational
  12. Tuberculosis susceptibility and protection in children.The Lancet. Infectious diseases · 2019
    Review
  13. Article
  14. Review
  15. Review
  16. Vaccine responses in newborns.Seminars in immunopathology · 2017
    Review
  17. Observational
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

Christine E JonesaAcademic Department of Pediatrics, Imperial College London, London, UK bInstitute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa cPaediatric Infectious Diseases Research Group, St George's, University of London, London, UK dDesmond Tutu TB Centre, Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Stellenbosch eSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town fDST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University gDivision of Statistics and Actuarial Sciences, Faculty of Science, University of Stellenbosch, Stellenbosch, South Africa hMRC National Institute for Medical Research, Mill Hill, London, UK iClinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa jDivision of Medicine, Imperial College London, London, UK kVaccinology Theme, Medical Research Council Unit, Banjul, The Gambia.
Anneke C Hesseling
Nontobeko G Tena-Coki
Thomas J Scriba
Novel N Chegou
Martin Kidd
Robert J Wilkinson
Beate Kampmann
Imperial College London · GBStellenbosch University · ZANational Institute of Research in Tuberculosis · INSouth African Tuberculosis Vaccine Initiative · ZASt George's, University of London · GBUniversity of Cape Town · ZA

Funding

Department of Health SRF-2009-02-07Medical Research Council MC_EX_MR/K011944/1Medical Research Council MC_UP_A900_1122Medical Research Council MC_UP_A900/115Medical Research Council MR/K007602/1Medical Research Council MR/K011944/1Medical Research Council U1175.02.0002.00014Wellcome Trust 077273Wellcome Trust 084323Wellcome Trust 088316Wellcome Trust 104803
6 · The paper itself

Abstract

objectiveThe objective of this study is to assess the effect of maternal HIV and Mycobacterium tuberculosis (Mtb) infection on cellular responses to bacille Calmette-Guérin (BCG) immunization.

designA mother-infant cohort study.

methodsSamples were collected from mother-infant pairs at delivery. Infants were BCG-vaccinated at 6 weeks of age and a repeat blood sample was collected from infants at 16 weeks of age. BCG-specific T-cell proliferation and intracellular cytokine expression were measured by flow cytometry. Secreted cytokines and chemokines in cell culture supernatants were analysed using a Multiplex assay.

resultsOne hundred and nine (47 HIV-exposed and 62 HIV-unexposed) mother-infants pairs were recruited after delivery and followed longitudinally. At birth, proportions of mycobacteria-specific proliferating T cells were not associated with either in-utero HIV exposure or maternal Mtb sensitization. However, in-utero HIV exposure affected infant-specific T-cell subsets [tumour necrosis factor-alpha (TNF-α) single positive proliferating CD4⁺ T cells and interferon-gamma (IFN-γ), TNF-α dual-positive CD4⁺ T cells]. Levels of TNF-α protein in cell culture supernatants were also significantly higher in HIV-exposed infants born to Mtb-sensitized mothers. In the presence of maternal Mtb sensitization, frequencies of maternal and newborn BCG-specific proliferating CD4⁺ T cells were positively correlated. Following BCG vaccination, there was no demonstrable effect of HIV exposure or maternal Mtb infection on infant BCG-specific T-cell proliferative responses or concentrations of secreted cytokines and chemokines.

conclusionEffects of maternal HIV and Mtb infection on infant immune profiles at birth are transient only, and HIV-exposed, noninfected infants have the same potential to respond to and be protected by BCG vaccination as HIV-unexposed infants.

Indexed as

AdultBCG VaccineCD4-Positive T-LymphocytesCohort StudiesFemaleHIV InfectionsHumansImmunity, CellularInfantInterferon-gammaMaternal ExposureMycobacterium tuberculosisPregnancyPregnancy Complications, InfectiousT-Lymphocyte SubsetsTuberculosisBCG VaccineInterferon-gammaTumor Necrosis Factor-alpha

Identifiers

PMID25535752
PMCPMC4284011
OpenAlexW2071975155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.