ArticleJournal of ginseng research2015
Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions.
Article in Journal of ginseng research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 74 citations in OpenAlex.
- Formulation And Evaluation Of Nanostructured Lipid Carriers (NLCs) Of 20(S)-Protopanaxadiol (PPD) By Box-Behnken Design.International journal of nanomedicine · 2019Trial
- Protopanaxatriol ameliorates diabetic retinopathy by regulating mTOR/G6PD mediated pentose phosphate pathway.Journal of natural medicines · 2026Article
- Integrative multi-omics and computational modeling reveal RPL22-driven skin aging mechanisms under PM2.5 exposure and identify high-stability natural inhibitors.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Compound K Promotes Megakaryocytic Differentiation by NLRP3 Inflammasome Activation.Biomolecules · 2024Article
- Synthesis, Anti-Inflammatory Activities, and Molecular Docking Study of Novel Pyxinol Derivatives as Inhibitors of NF-κB Activation.Molecules (Basel, Switzerland) · 2024Article
- Protopanaxadiol-Enriched Rice Exerted Antiadipogenic Activity during 3T3-L1 Differentiation and Anti-Inflammatory Activity in 3T3-L1 Adipocytes.Pharmaceutics · 2023Article
- Comparison of the Effects ofAnimals : an open access journal from MDPI · 2023Article
- Effect of Ginseng Sapogenin Protopanaxadiol-Enriched Rice (DJ-PPD) on Immunomodulation.Plants (Basel, Switzerland) · 2023Article
- Design, Synthesis, and Anti-Inflammatory Activities of 12-Dehydropyxinol Derivatives.Molecules (Basel, Switzerland) · 2023Article
- Transgenic Rice Seed Extracts Exert Immunomodulatory Effects by Modulating Immune-Related Biomarkers in RAW264.7 Macrophage Cells.Nutrients · 2022Article
- Korean Red Ginseng water extract inhibits cadmium-induced lung injury via suppressing MAPK/ERK1/2/AP-1 pathway.Journal of ginseng research · 2022Article
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- The Anti-Tumor Effect and Underlying Apoptotic Mechanism of Ginsenoside Rk1 and Rg5 in Human Liver Cancer Cells.Molecules (Basel, Switzerland) · 2021Article
- Advances in Experimental and Clinical Research of the Gouty Arthritis Treatment with Traditional Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Inhibition of long noncoding RNA HIF1A-AS2 confers protection against atherosclerosisJournal of advanced research · 2020Article
- Synthesis and Structure-Activity Relationship of Pyxinol Derivatives as Novel Anti-Inflammatory Agents.ACS medicinal chemistry letters · 2020Article
- Specific Interaction With Human Serum Albumin Reduces Ginsenoside Cytotoxicity in Human Umbilical Vein Endothelial Cells.Frontiers in pharmacology · 2020Article
- AKT-targeted anti-inflammatory activity ofJournal of ginseng research · 2018Article
- The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng.Journal of ginseng research · 2018Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKorean Red Ginseng (KRG) is a representative traditional herbal medicine with many different pharmacological properties including anticancer, anti-atherosclerosis, anti-diabetes, and anti-inflammatory activities. Only a few studies have explored the molecular mechanism of KRG-mediated anti-inflammatory activity.
methodsWe investigated the anti-inflammatory mechanisms of the protopanaxadiol saponin fraction (PPD-SF) of KRG using in vitro and in vivo inflammatory models.
resultsPPD-SF dose-dependently diminished the release of inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α, and prostaglandin E2], and downregulated the mRNA expression of their corresponding genes (inducible NO synthase, tumor necrosis factor-α, and cyclooxygenase-2), without altering cell viability. The PPD-SF-mediated suppression of these events appeared to be regulated by a blockade of p38, c-Jun N-terminal kinase (JNK), and TANK (TRAF family member-associated NF-kappa-B activator)-binding kinase 1 (TBK1), which are linked to the activation of activating transcription factor 2 (ATF2) and interferon regulatory transcription factor 3 (IRF3). Moreover, this fraction also ameliorated HCl/ethanol/-induced gastritis via suppression of phospho-JNK2 levels.
conclusionThese results strongly suggest that the anti-inflammatory action of PPD-SF could be mediated by a reduction in the activation of p38-, JNK2-, and TANK-binding-kinase-1-linked pathways and their corresponding transcription factors (ATF2 and IRF3).
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