ReviewJournal of ginseng research2015
Effect of ginseng and ginsenosides on melanogenesis and their mechanism of action.
Review in Journal of ginseng research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Characterization of terpene extract from Cannabis sativa flower and evaluation of its anti-melanogenetic effect in melan-a cells.Scientific reports · 2025Article
- Enhancement of skin regeneration through activation ofJournal of ginseng research · 2025Article
- Coinhibitory Effects of Resveratrol- and Protopanaxadiol-Enriched Rice Seed Extracts Against Melanogenic Activities in Melan-a Cells.Plants (Basel, Switzerland) · 2024Article
- Ginseng and ginseng byproducts for skincare and skin health.Journal of ginseng research · 2024Review
- Self-assembled gel microneedle formed by MS deep eutectic solvent as a transdermal delivery system for hyperpigmentation treatment.Materials today. Bio · 2024Article
- Mass spectrometry-based ginsenoside profiling: Recent applications, limitations, and perspectives.Journal of ginseng research · 2024Review
- Biotransformation of ginsenoside RbJournal of natural medicines · 2023Article
- Discrepancy Study of the Chemical Constituents of Panax Ginseng from Different Growth Environments with UPLC-MS-Based Metabolomics Strategy.Molecules (Basel, Switzerland) · 2023Article
- Protopanaxadiol-Enriched Rice Extracts Suppressed Oxidative and Melanogenic Activities in Melan-a Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms.Drug design, development and therapy · 2023Review
- Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications.Molecules (Basel, Switzerland) · 2022Review
- Synergistic effects of novel herbal decoctions fromHeliyon · 2022Article
- Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes.Journal of ginseng research · 2022Article
- The regulatory role of Korean ginseng in skin cells.Journal of ginseng research · 2021Review
- Article
- Comparative transcriptome analysis of the protective effects of Korean Red Ginseng against the influence of bisphenol A in the liver and uterus of ovariectomized mice.Journal of ginseng research · 2020Article
- Anti-Melanogenic Effect from Submerged Mycelial Cultures ofMycobiology · 2019Article
- Microemulsion-based hydrogels for enhancing epidermal/dermal deposition of topically administered 20(Journal of ginseng research · 2018Article
- Antimelanogenesis and skin-protective activities ofJournal of ginseng research · 2018Article
- An Insight into Ginsenoside Metabolite Compound K as a Potential Tool for Skin Disorder.Evidence-based complementary and alternative medicine : eCAM · 2018Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal changes in skin color induce significant cosmetic problems and affect quality of life. There are two groups of abnormal change in skin color; hyperpigmentation and hypopigmentation. Hyperpigmentation, darkening skin color by excessive pigmentation, is a major concern for Asian people with yellow-brown skin. A variety of hypopigmenting agents have been used, but treating the hyperpigmented condition is still challenging and the results are often discouraging. Panax ginseng has been used traditionally in eastern Asia to treat various diseases, due to its immunomodulatory, neuroprotective, antioxidative, and antitumor activities. Recently, several reports have shown that extract, powder, or some constituents of ginseng could inhibit melanogenesis in vivo or in vitro. The underlying mechanisms of antimelanogenic properties in ginseng or its components include the direct inhibition of key enzymes of melanogenesis, inhibition of transcription factors or signaling pathways involved in melanogenesis, decreasing production of inducers of melanogenesis, and enhancing production of antimelanogenic factor. Although there still remain some controversial issues surrounding the antimelanogenic activity of ginseng, especially in its effect on production of proinflammatory cytokines and nitric oxide, these recent findings suggest that ginseng and its constituents might be potential candidates for novel skin whitening agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.