ArticleProceedings of the National Academy of Sciences of the United States of America2015
Pan-vertebrate comparative genomics unmasks retrovirus macroevolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed, 182 citations in OpenAlex.
- An ancient alpharetrovirus lineage in bats: Evolutionary insights and possible roles in reproduction.PLoS genetics · 2026Article
- Gammaretrovirus Infections in Humans in the Past, Present, and Future: Have We Defeated the Pathogen?Pathogens (Basel, Switzerland) · 2026Review
- Retroviral insertions contributed to the divergence of human and chimpanzee brains.bioRxiv : the preprint server for biology · 2025Article
- Transcriptome mining reveals diversity and evolution of circulating and endogenous amphibian retroviruses.Retrovirology · 2025Article
- HI-FEVER: a Nextflow pipeline for the high-throughput discovery and annotation of endogenous viral elements.Bioinformatics (Oxford, England) · 2025Article
- Insertion of an invading retrovirus regulates a novel color trait in swordtail fish.bioRxiv : the preprint server for biology · 2025Article
- Diversity and evolutionary history of endogenous retroviruses in the genome ofMicrobiology spectrum · 2025Article
- Endogenous Retroviruses in Host-Virus Coevolution: From Genomic Domestication to Functional Innovation.Genes · 2025Review
- Discovery of endogenous retroviruses in the genome of the red panda (Microbiology spectrum · 2025Article
- Phylogenomics Unveils the Complex Evolution of Retroviruses in Birds.Molecular biology and evolution · 2025Article
- The snakehead retrovirus promoter functions independently of the 3'ORF protein and its products are maternally inherited in transgenic zebrafish.PLoS pathogens · 2025Article
- Unraveling The Impact of Viral Infections on Sperm Genetic Stability: A Scoping Review.International journal of fertility & sterility · 2025Article
- A genome-wide study of ruminants uncovers two endogenous retrovirus families recently active in goats.Mobile DNA · 2025Article
- Signature of viral fossils: a comparative genomics approach to understand the diversity of endogenous retroviruses in bats.Virus research · 2024Article
- Article
- Review
- Invasion and Amplification of Endogenous Retroviruses in Dasyuridae Marsupial Genomes.Molecular biology and evolution · 2024Article
- A novel approach to exploring the dark genome and its application to mapping of the vertebrate virus fossil record.Genome biology · 2024Article
- Exploring the role of endogenous retroviruses in seasonal reproductive cycles: a case study of the ERV-V envelope gene in mink.Frontiers in cellular and infection microbiology · 2024Article
- Genealogical Diversity of Endogenous Retrovirus in the Jawless Fish Genome.Journal of microbiology and biotechnology · 2023Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although extensive research has demonstrated host-retrovirus microevolutionary dynamics, it has been difficult to gain a deeper understanding of the macroevolutionary patterns of host-retrovirus interactions. Here we use recent technological advances to infer broad patterns in retroviral diversity, evolution, and host-virus relationships by using a large-scale phylogenomic approach using endogenous retroviruses (ERVs). Retroviruses insert a proviral DNA copy into the host cell genome to produce new viruses. ERVs are provirus insertions in germline cells that are inherited down the host lineage and consequently present a record of past host-viral associations. By mining ERVs from 65 host genomes sampled across vertebrate diversity, we uncover a great diversity of ERVs, indicating that retroviral sequences are much more prevalent and widespread across vertebrates than previously appreciated. The majority of ERV clades that we recover do not contain known retroviruses, implying either that retroviral lineages are highly transient over evolutionary time or that a considerable number of retroviruses remain to be identified. By characterizing the distribution of ERVs, we show that no major vertebrate lineage has escaped retroviral activity and that retroviruses are extreme host generalists, having an unprecedented ability for rampant host switching among distantly related vertebrates. In addition, we examine whether the distribution of ERVs can be explained by host factors predicted to influence viral transmission and find that internal fertilization has a pronounced effect on retroviral colonization of host genomes. By capturing the mode and pattern of retroviral evolution and contrasting ERV diversity with known retroviral diversity, our study provides a cohesive framework to understand host-virus coevolution better.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.