ArticleProceedings of the National Academy of Sciences of the United States of America2015
Evolutionary pattern in the OXT-OXTR system in primates: coevolution and positive selection footprints.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys.Psychoneuroendocrinology · 2016Trial
- Oxytocin Variants Induce Cellular Signaling and Neurite Outgrowth in Human-Derived Neuron-like SH-SY5Y Cell Line.NeuroSci · 2026Article
- Comparative genomic analysis of oxytocin and oxytocin receptor genes in the family Equidae.Molecular biology reports · 2026Article
- Computational modeling of oxytocin-receptors interactions with the common marmoset Callithrix jacchus Pro8OT variant.Genetics and molecular biology · 2025Article
- An evolutionary timeline of the oxytocin signaling pathway.Communications biology · 2024Article
- Involvement of Protein Kinase A in Oxytocin Neuronal Activity in Rat Dams with Pup Deprivation.Neurochemical research · 2021Article
- Vasopressin, but not oxytocin, modulates responses to infant stimuli in marmosets providing care to dependent infants.Developmental psychobiology · 2020Article
- Using High-Density SNP Array to Reveal Selection Signatures Related to Prolificacy in Chinese and Kazakhstan Sheep Breeds.Animals : an open access journal from MDPI · 2020Article
- Comparison of the pharmacological profiles of arginine vasopressin and oxytocin analogs at marmoset, macaque, and human vasopressin 1a receptor.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Article
- Comparison of the pharmacologic profiles of arginine vasopressin and oxytocin analogs at marmoset, titi monkey, macaque, and human oxytocin receptors.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Article
- Transcriptome of the Southern MuriquiFrontiers in genetics · 2020Article
- LeuScientific reports · 2019Article
- A Comparison of the Ability of LeuMolecular pharmacology · 2019Article
- Oxytocin structure and function in New World monkeys: from pharmacology to behavior.Integrative zoology · 2018Review
- Oxytocin regulates reunion affiliation with a pairmate following social separation in marmosets.American journal of primatology · 2018Article
- Binding Characteristics of Two Oxytocin Variants and Vasopressin at Oxytocin Receptors from Four Primate Species with Different Social Behavior Patterns.The Journal of pharmacology and experimental therapeutics · 2018Article
- Opportunities and challenges for intranasal oxytocin treatment studies in nonhuman primates.American journal of primatology · 2018Article
- Oxytocin and arginine vasopressin systems in the domestication process.Genetics and molecular biology · 2018Article
- Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Microsatellite Polymorphisms Adjacent to the Oxytocin Receptor Gene in Domestic Cats: Association with Personality?Frontiers in psychology · 2017Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxytocin is a nonapeptide involved in a wide range of physiologic and behavioral functions. Until recently, it was believed that an unmodified oxytocin sequence was present in all placental mammals. This study analyzed oxytocin (OXT) in 29 primate species and the oxytocin receptor (OXTR) in 21 of these species. We report here three novel OXT forms in the New World monkeys, as well as a more extensive distribution of a previously described variant (Leu8Pro). In structural terms, these OXTs share the same three low-energy conformations in solution during molecular dynamic simulations, with subtle differences in their side chains. A consistent signal of positive selection was detected in the Cebidae family, and OXT position 8 showed a statistically significant (P = 0.013) correlation with litter size. Several OXTR changes were identified, some of them promoting gain or loss of putative phosphorylation sites, with possible consequences for receptor internalization and desensitization. OXTR amino acid sites are under positive selection, and intramolecular and intermolecular coevolutionary processes with OXT were also detected. We suggest that some New World monkey OXT-OXTR forms can be correlated to male parental care through the increase of cross-reactivity with its correlated vasopressin system.
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