ArticleProceedings of the National Academy of Sciences of the United States of America2015
Fear and C-reactive protein cosynergize annual pulse increases in healthy adults.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
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- Obesity-related acetylcholinesterase elevation is reversed following laparoscopic sleeve gastrectomy.International journal of obesity (2005) · 2019Article
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- Septic patients presenting with apparently normal C-reactive protein: A point of caution for the ER physician.Medicine · 2019Observational
- Total serum cholinesterase activity predicts hemodynamic changes during exercise and associates with cardiac troponin detection in a sex-dependent manner.Molecular medicine (Cambridge, Mass.) · 2018Article
- A risk prediction model for post-stroke depression in Chinese stroke survivors based on clinical and socio-psychological features.Oncotarget · 2017Article
- Mexico's epidemic of violence and its public health significance on average length of life.Journal of epidemiology and community health · 2017Article
- Weakened Cholinergic Blockade of Inflammation Associates with Diabetes-Related Depression.Molecular medicine (Cambridge, Mass.) · 2016Article
- Intensified vmPFC surveillance over PTSS under perturbed microRNA-608/AChE interaction.Translational psychiatry · 2016Article
- Fear of terror and inflammation ignite heart health decline.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation.Frontiers in cellular neuroscience · 2015Article
- The expression patterns of MALAT-1, NEAT-1, THRIL, and miR-155-5p in the acute to the post-acute phase of COVID-19 disease.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent international terror outbreaks notably involve long-term mental health risks to the exposed population, but whether physical health risks are also anticipated has remained unknown. Here, we report fear of terror-induced annual increases in resting heart rate (pulse), a notable risk factor of all-cause mortality. Partial least squares analysis based on 325 measured parameters successfully predicted annual pulse increases, inverse to the expected age-related pulse decline, in approximately 4.1% of a cohort of 17,380 apparently healthy active Israeli adults. Nonbiased hierarchical regression analysis among 27 of those parameters identified pertinent fear of terror combined with the inflammatory biomarker C-reactive protein as prominent coregulators of the observed annual pulse increases. In comparison, basal pulse primarily depended on general physiological parameters and reduced cholinergic control over anxiety and inflammation, together indicating that consistent exposure to terror threats ignites fear-induced exacerbation of preexisting neuro-immune risks of all-cause mortality.
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