Evidence map›Paper›PMID 25535358›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2015

Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness.

Anne-Marie Chang, Daniel Aeschbach, Jeanne F Duffy, Charles A Czeisler

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05555186 (Effect of School Based Ambient Bright White Light Intervention on Adolescents´ Sleep Quality, Depression and Mood), which is not on this map. Cited by 536 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
536citing papers in PubMed, 2 pooled it
27.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05555186 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of School Based Ambient Bright White Light Intervention on Adolescents´ Sleep Quality, Depression and Mood

TypeinterventionalSponsorReykjavik UniversityRan2022 to 2023Enrolled240ConditionsSleep Disturbance, Depression, Mood, Circadian RhythmsArmsBWL classrooms (Experimental), DWL classrooms (Comparison)
3 · Its place in the literature

Who cites it

536 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,302 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Blue-Light Filters in Eye Care: A State-of-the-Art Review.Medical sciences (Basel, Switzerland) · 2026
    Review
  7. Article
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  11. Review
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  17. Observational
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476 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Anne-Marie ChangDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115; and amchang@psu.edu.
Daniel AeschbachDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115; and Institute of Aerospace Medicine, German Aerospace Center, 51147 Cologne, Germany.
Jeanne F DuffyDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115; and.
Charles A CzeislerDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115; and.
Brigham and Women's Hospital · USHarvard University · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Adaptation of Circadian Responses to Light TreatmentR01HL077453 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DUFFY, JEANNE F · 2004 to 2010
$2.6M
Sensitization of Human Circadian Responses to LightR01HL094654 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A · 2010 to 2013
$1.2M
Effect of circadian gene variants on sleep, obesity, and metabolic phenotypesK01HL115458 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI CHANG, ANNE-MARIE · 2012 to 2014
$408k
NCRR NIH HHS UL1 RR025758NHLBI NIH HHS K01 HL115458NHLBI NIH HHS K01HL115458NHLBI NIH HHS R01 HL077453NHLBI NIH HHS R01HL077453NHLBI NIH HHS R01 HL094654NHLBI NIH HHS R01HL094654
6 · The paper itself

Abstract

In the past 50 y, there has been a decline in average sleep duration and quality, with adverse consequences on general health. A representative survey of 1,508 American adults recently revealed that 90% of Americans used some type of electronics at least a few nights per week within 1 h before bedtime. Mounting evidence from countries around the world shows the negative impact of such technology use on sleep. This negative impact on sleep may be due to the short-wavelength-enriched light emitted by these electronic devices, given that artificial-light exposure has been shown experimentally to produce alerting effects, suppress melatonin, and phase-shift the biological clock. A few reports have shown that these devices suppress melatonin levels, but little is known about the effects on circadian phase or the following sleep episode, exposing a substantial gap in our knowledge of how this increasingly popular technology affects sleep. Here we compare the biological effects of reading an electronic book on a light-emitting device (LE-eBook) with reading a printed book in the hours before bedtime. Participants reading an LE-eBook took longer to fall asleep and had reduced evening sleepiness, reduced melatonin secretion, later timing of their circadian clock, and reduced next-morning alertness than when reading a printed book. These results demonstrate that evening exposure to an LE-eBook phase-delays the circadian clock, acutely suppresses melatonin, and has important implications for understanding the impact of such technologies on sleep, performance, health, and safety.

Indexed as

Circadian RhythmReadingSleepAdultFemaleHumansLightingMaleMelatoninSleep Wake DisordersMelatoninchronobiologydigital mediaelectronicsphase-shiftingsleep

Identifiers

PMID25535358
PMCPMC4313820
OpenAlexW2103257619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.