ArticleProceedings of the National Academy of Sciences of the United States of America2015
Patterns of genome evolution that have accompanied host adaptation in Salmonella.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.
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156 citing papers in PubMed.
- Pan genome clustering identifies a novel mosaic prophage specific to Salmonella Enteritidis lineage associated with the invasive disease in India.PLoS neglected tropical diseases · 2026Article
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- Host adaptation inApplied and environmental microbiology · 2026Review
- Bacterial metabolic remodeling by convergent evolution unlocks nutrient availability after a host switch.Science advances · 2026Article
- PagN: a multifunctional outer membrane protein in Salmonella virulence and host interaction.Archives of microbiology · 2026Review
- Defence systems drive accessory genome interactions inISME communications · 2026Article
- Genomic and epidemiologic evidence for attenuated virulence inFrontiers in microbiology · 2026Article
- The SPI-20 and SPI-21 T6SS gene clusters fromFrontiers in microbiology · 2026Article
- Comparative genomic and ecological insights intoFrontiers in microbiology · 2026Article
- Comparative genomics ofVirulence · 2025Article
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- A Toxin of Valsa mali Determines Virulence and Host Preference.Molecular plant pathology · 2025Article
- Molecular epidemiology ofAntimicrobial agents and chemotherapy · 2025Article
- aurora: a machine learning gwas tool for analyzing microbial habitat adaptation.Genome biology · 2025Article
- A genomic and phenotypic investigation of pigeon-adaptive Salmonella.PLoS pathogens · 2025Article
- Review
- Comparative genomics analysis of Salmonella Enteritidis isolated from clinical cases associated with chicken.BMC microbiology · 2024Article
- Uncovering newMicrobiology spectrum · 2024Article
- A host shift as the origin of tomato bacterial canker caused byMicrobial genomics · 2024Article
96 more citing papers are in PubMed but not listed here.
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19 authors.
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Abstract
Many bacterial pathogens are specialized, infecting one or few hosts, and this is often associated with more acute disease presentation. Specific genomes show markers of this specialization, which often reflect a balance between gene acquisition and functional gene loss. Within Salmonella enterica subspecies enterica, a single lineage exists that includes human and animal pathogens adapted to cause infection in different hosts, including S. enterica serovar Enteritidis (multiple hosts), S. Gallinarum (birds), and S. Dublin (cattle). This provides an excellent evolutionary context in which differences between these pathogen genomes can be related to host range. Genome sequences were obtained from ∼ 60 isolates selected to represent the known diversity of this lineage. Examination and comparison of the clades within the phylogeny of this lineage revealed signs of host restriction as well as evolutionary events that mark a path to host generalism. We have identified the nature and order of events for both evolutionary trajectories. The impact of functional gene loss was predicted based upon position within metabolic pathways and confirmed with phenotyping assays. The structure of S. Enteritidis is more complex than previously known, as a second clade of S. Enteritidis was revealed that is distinct from those commonly seen to cause disease in humans or animals, and that is more closely related to S. Gallinarum. Isolates from this second clade were tested in a chick model of infection and exhibited a reduced colonization phenotype, which we postulate represents an intermediate stage in pathogen-host adaptation.
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