ArticleThe American journal of tropical medicine and hygiene2015
Imported pythium insidiosum keratitis after a swim in Thailand by a contact lens-wearing traveler.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Case Report: Poor Outcome Despite Aggressive Management in Pythium insidiosum Endophthalmitis.The American journal of tropical medicine and hygiene · 2023Article
- Outcomes of Pythium keratitis: a meta-analysis of individual patient data.Current ophthalmology reports · 2022Article
- Pythium insidiosum Keratitis: Past, Present, and Future.Ophthalmology and therapy · 2022Review
- Review
- Global Distribution and Clinical Features of Pythiosis in Humans and Animals.Journal of fungi (Basel, Switzerland) · 2022Article
- History and Perspective of Immunotherapy for Pythiosis.Vaccines · 2021Review
- Retrospective multifactorial analysis ofIndian journal of ophthalmology · 2021Review
- Clinical Characteristics, Histopathology, and Treatment Outcomes ofClinical ophthalmology (Auckland, N.Z.) · 2021Article
- Review
- Article
- Article
- Fungal keratitis: study of increasing trend and common determinants.Nepal journal of epidemiology · 2017Article
- Minimal inhibitory concentration distributions and epidemiological cutoff values of five antifungal agents against Sporothrix brasiliensis.Memorias do Instituto Oswaldo Cruz · 2017Article
- Diagnosis and Treatment of Pythium Insidiosum Corneal Ulcer in a Chinese Child: A Case Report and Literature Review.The American journal of case reports · 2016Review
- Water related ocular diseases.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyReview
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 30-year-old woman with a history of contact lens wear and exposure to swimming pool water in Thailand presented with a non-responsive, progressive corneal ulcer of the right eye. Confocal microscopy evidenced septate linear branching structures, raising suspicion of fungal keratitis. She was promptly treated with topical antibiotics and both topical and intravenous caspofungin plus voriconazole. Worsening of the clinical picture after 1 month of intensive medical therapy led to a large therapeutic penetrating keratoplasty being performed. Corneal cultures grew a mold-like organism, which was identified by sequencing as Pythium insidiosum, an aquatic oomycete. After 4 years of follow-up, the graft exhibits no infection relapse, but graft transparency has been lost after two rejection episodes. Keratoplasty combined with antifungal treatment may offer a cure to P. insidiosum keratitis, although long-term preservation of corneal transparency is difficult to obtain.
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Registered trials
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