Evidence map›Paper›PMID 25535301›Full record

Observational studyJournal of the American Society of Nephrology : JASN2015

Tissue Inhibitor Metalloproteinase-2 (TIMP-2)⋅IGF-Binding Protein-7 (IGFBP7) Levels Are Associated with Adverse Long-Term Outcomes in Patients with AKI.

Jay L Koyner, Andrew D Shaw, Lakhmir S Chawla, Eric A J Hoste, Azra Bihorac, Kianoush Kashani, Michael Haase, Jing Shi, John A Kellum, Sapphire Investigators

Registry-linked trialAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07294911 (Predictors of Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndrome), which is not on this map. Cited by 115 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07294911 completednot on this mapstarted 2024, after this paper: background citation

Predictors of Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndrome

TypeobservationalSponsorKaraganda Medical UniversityRan2024 to 2025Enrolled88ConditionsAcute Coronary Syndrome, Contrast-Induced Acute Kidney InjuryArmsObservational data collection
3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Observational
  12. Review
  13. IGF-Binding Protein 7 and Cadmium-Induced Hepatorenal Fibrosis.Journal of the American Society of Nephrology : JASN · 2025
    Article
  14. Review
  15. Article
  16. Matrix metalloproteinases in kidney homeostasis and diseases: an update.American journal of physiology. Renal physiology · 2024
    Review
  17. Early Diagnostic and Prognostic Value of the Urinary TIMP-2 and IGFBP-7 in Acute Kidney Injury in Critically Ill Children.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
  18. Biomarkers in acute kidney injury.Annals of intensive care · 2024
    Review
  19. Article
  20. Observational

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jay L KoynerSection of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois;
Andrew D ShawDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee;
Lakhmir S ChawlaDepartment of Medicine, Divisions of Intensive Care Medicine and Nephrology, Washington DC Veterans Affairs Medical Center, Washington DC;
Eric A J HosteDepartment of Intensive Care Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium;
Azra BihoracDepartment of Anesthesiology, University of Florida, Gainesville, Florida;
Kianoush KashaniDepartment of Medicine, Division of Nephrology and Hypertension and Division of Pulmonary Critical Care Medicine, Mayo Clinic, Rochester, Minnesota;
Michael HaaseDepartment of Nephrology, Hypertension, Diabetes and Endocrinology, Otto von Guericke University, Magdeburg, Germany;
Jing ShiStatistics at Walker BioSciences, Carlsbad, California; and.
John A KellumCenter for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania kellumja@ccm.upmc.edu.
Sapphire Investigators

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
NCATS NIH HHS UL1 TR000430
6 · The paper itself

Abstract

Tissue inhibitor metalloproteinase-2 (TIMP-2) and IGF-binding protein-7 (IGFBP7) have been validated for risk stratification in AKI. However, the association of urinary TIMP-2 and IGFBP7 with long-term outcomes is unknown. We evaluated the 9-month incidence of a composite end point of all-cause mortality or the need for RRT in a secondary analysis of a prospective observational international study of critically ill adults. Two predefined [TIMP-2]⋅[IGFBP7] cutoffs (0.3 for high sensitivity and 2.0 for high specificity) for the development of AKI were evaluated. Cox proportional hazards models were used to determine risk for the composite end point. Baseline [TIMP-2]⋅[IGFBP7] values were available for 692 subjects, of whom 382 (55.2%) subjects developed stage 1 AKI (defined by Kidney Disease Improving Global Outcomes guidelines) within 72 hours of enrollment and 217 (31.4%) subjects met the composite end point. Univariate analysis showed that [TIMP-2]⋅[IGFBP7]>2.0 was associated with increased risk of the composite end point (hazard ratio [HR], 2.11; 95% confidence interval [95% CI], 1.37 to 3.23; P<0.001). In a multivariate analysis adjusted for the clinical model, [TIMP-2]⋅[IGFBP7] levels>0.3 were associated with death or RRT only in subjects who developed AKI (compared with levels≤0.3: HR, 1.44; 95% CI, 1.00 to 2.06 for levels>0.3 to ≤2.0; P=0.05 and HR, 2.16; 95% CI, 1.32 to 3.53 for levels>2.0; P=0.002). In conclusion, [TIMP-2]⋅[IGFBP7] measured early in the setting of critical illness may identify patients with AKI at increased risk for mortality or receipt of RRT over the next 9 months.

Indexed as

Acute Kidney InjuryAdultBiomarkersCohort StudiesFemaleFollow-Up StudiesHumansInsulin-Like Growth Factor Binding ProteinsKaplan-Meier EstimateKidney Function TestsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProportional Hazards ModelsProspective StudiesBiomarkersinsulin-like growth factor binding protein-related protein 1Insulin-Like Growth Factor Binding ProteinsTissue Inhibitor of Metalloproteinase-2epidemiology and outcomeskidneymortality

Identifiers

PMID25535301
PMCPMC4483589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.