ArticlePlant physiology2015
CESA TRAFFICKING INHIBITOR inhibits cellulose deposition and interferes with the trafficking of cellulose synthase complexes and their associated proteins KORRIGAN1 and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1.
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Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 47 citations in OpenAlex.
- Plasma Membrane and Endomembrane Lipids Are Involved in a Complex Adaptation ofInternational journal of molecular sciences · 2026Article
- Expression patterns of Arabidopsis endo-β-1,4-glucanases and their putative roles in sexual reproduction.BMC plant biology · 2026Article
- A high-resolution model of gene expression during Gossypium hirsutum (cotton) fiber development.BMC genomics · 2025Article
- A cellulose synthesis inhibitor affects cellulose synthase complex secretion and cortical microtubule dynamics.Plant physiology · 2024Article
- Discovery and Characterization of Fluopipamine, a Putative Cellulose Synthase 1 Antagonist withinJournal of agricultural and food chemistry · 2024Article
- Breaking-Down Barriers: Proposal of Using Cellulose Biosynthesis Inhibitors and Cellulase Enzyme as a Novel Treatment Modality for Vision Threatening Pythium Insidiosum Keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Research overview on the genetic mechanism underlying the biosynthesis of polysaccharide in tuber plants.PeerJ · 2024Review
- Actomyosin and CSI1/POM2 cooperate to deliver cellulose synthase from Golgi to cortical microtubules in Arabidopsis.Nature communications · 2023Article
- Emerging Roles of β-Glucanases in Plant Development and Adaptative Responses.Plants (Basel, Switzerland) · 2022Review
- A G protein-coupled receptor-like module regulates cellulose synthase secretion from the endomembrane system in Arabidopsis.Developmental cell · 2021Article
- Endosidin20 Targets the Cellulose Synthase Catalytic Domain to Inhibit Cellulose Biosynthesis.The Plant cell · 2020Article
- An Improved Recombineering Toolset for Plants.The Plant cell · 2020Article
- Flax tubulin and CesA superfamilies represent attractive and challenging targets for a variety of genome- and base-editing applications.Functional & integrative genomics · 2020Review
- Genome Editing-Based Engineering of CESA3 Dual Cellulose-Inhibitor-Resistant Plants.Plant physiology · 2019Article
- The Regulation of Cellulose Biosynthesis in Plants.The Plant cell · 2019Review
- Alleles Causing Resistance to Isoxaben and Flupoxam Highlight the Significance of Transmembrane Domains for CESA Protein Function.Frontiers in plant science · 2018Article
- Post-Golgi Trafficking and Transport of Cell Wall Components.Frontiers in plant science · 2018Review
- The Plant Trans-Golgi Network: Not Just a Matter of Distinction.Plant physiology · 2018Review
- Actin filaments regulate the adhesion between the plasma membrane and the cell wall of tobacco guard cells.Protoplasma · 2018Article
- Two Complementary Mechanisms Underpin Cell Wall Patterning during Xylem Vessel Development.The Plant cell · 2017Article
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Authors and funding
13 authors at 6 institutions in 3 countries.
Natasha WordenDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.).ORCID http://orcid.org/0000-0002-0804-2884
Thomas E WilkopDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.).
Victor Esteva EsteveDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.).
Richard JeannotteDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.).
Rahul LatheDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.).
Samantha VernhettesDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.).
Bart WeimerDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.).
Glenn HicksDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.).
Jose AlonsoDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.).
John LabavitchDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.).
Staffan PerssonDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.).
David EhrhardtDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.).
Georgia DrakakakiDepartments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); andDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.) gdrakakaki@ucdavis.edu.
Institut Jean-Pierre Bourgin · FRMax Planck Institute of Molecular Plant Physiology · DEAgroParisTech · FRCarnegie Department of Plant Biology · USUniversity of California, Davis · USUniversity of California, Riverside · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellulose synthase complexes (CSCs) at the plasma membrane (PM) are aligned with cortical microtubules (MTs) and direct the biosynthesis of cellulose. The mechanism of the interaction between CSCs and MTs, and the cellular determinants that control the delivery of CSCs at the PM, are not yet well understood. We identified a unique small molecule, CESA TRAFFICKING INHIBITOR (CESTRIN), which reduces cellulose content and alters the anisotropic growth of Arabidopsis (Arabidopsis thaliana) hypocotyls. We monitored the distribution and mobility of fluorescently labeled cellulose synthases (CESAs) in live Arabidopsis cells under chemical exposure to characterize their subcellular effects. CESTRIN reduces the velocity of PM CSCs and causes their accumulation in the cell cortex. The CSC-associated proteins KORRIGAN1 (KOR1) and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1 (CSI1) were differentially affected by CESTRIN treatment, indicating different forms of association with the PM CSCs. KOR1 accumulated in bodies similar to CESA; however, POM2/CSI1 dissociated into the cytoplasm. In addition, MT stability was altered without direct inhibition of MT polymerization, suggesting a feedback mechanism caused by cellulose interference. The selectivity of CESTRIN was assessed using a variety of subcellular markers for which no morphological effect was observed. The association of CESAs with vesicles decorated by the trans-Golgi network-localized protein SYNTAXIN OF PLANTS61 (SYP61) was increased under CESTRIN treatment, implicating SYP61 compartments in CESA trafficking. The properties of CESTRIN compared with known CESA inhibitors afford unique avenues to study and understand the mechanism under which PM-associated CSCs are maintained and interact with MTs and to dissect their trafficking routes in etiolated hypocotyls.
Indexed as
AnisotropyArabidopsisArabidopsis ProteinsBenzamidesCarrier ProteinsCell CompartmentationCell MembraneCellulaseCelluloseDinitrobenzenesEnzyme InhibitorsGlucoseGlucosyltransferasesGreen Fluorescent ProteinsHypocotylMembrane ProteinsArabidopsis ProteinsBenzamidesCarrier ProteinsCellulaseCellulosecellulose synthaseCSI1 protein, ArabidopsisDinitrobenzenesEnzyme InhibitorsGlucoseGlucosyltransferasesGreen Fluorescent ProteinsisoxabenKOR1 protein, ArabidopsisMembrane ProteinsMultiprotein ComplexesoryzalinSulfanilamides
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