Evidence map›Paper›PMID 25535225›Full record

ArticleBMJ case reports2014

Fatal lymphomatoid granulomatosis with primary CNS-involvement in an immunocompetent 80-year-old woman.

David G Olmes, Abbas Agaimy, Stephan Kloska, Ralf A Linker

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

David G OlmesDepartment of Neurology, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Abbas AgaimyInstitute of Pathology, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Stephan KloskaDepartment of Neuroradiology, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Ralf A LinkerDepartment of Neurology, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEErlang Solutions (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 80-year-old woman presented with weight loss, fatigue, dizziness and a brain stem lesion. Extensive work-up revealed lymphomatoid granulomatosis (LYG) with primary clinical manifestation in the central nervous system (CNS), a rare Epstein-Barr virus-driven multisystem lymphoproliferative disorder, to be causative for the symptoms. Immunochemotherapy consisting of rituximab and temozolomide was started, but the disease progressed and the patient subsequently died. Histology, diagnostic criteria, differential diagnosis and treatment options for LYG with CNS involvement are discussed. This case demonstrates that LYG with CNS involvement may necessitate more aggressive treatment approaches than combination therapy with rituximab and temozolomide.

Indexed as

Aged, 80 and overAntibodies, Monoclonal, Murine-DerivedAntineoplastic AgentsCentral Nervous SystemCentral Nervous System NeoplasmsDacarbazineFatal OutcomeFemaleHerpesvirus 4, HumanHumansLymphomatoid GranulomatosisRituximabTemozolomideAntibodies, Monoclonal, Murine-DerivedAntineoplastic AgentsDacarbazineRituximabTemozolomide

Identifiers

PMID25535225
PMCPMC4275695
OpenAlexW2313426753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.