ReviewInternational journal of molecular sciences2014
From end to end: tRNA editing at 5'- and 3'-terminal positions.
Review in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- tRNA modifications in cancer: from molecular mechanisms to clinical translation.Biomarker research · 2026Review
- A comparison ofbioRxiv : the preprint server for biology · 2025Article
- BeyondChemical reviews · 2025Review
- Thg1 family 3'-5' RNA polymerases as tools for targeted RNA synthesis.RNA (New York, N.Y.) · 2024Article
- The molecular language of RNA 5' ends: guardians of RNA identity and immunity.RNA (New York, N.Y.) · 2024Review
- Comparative mitogenome analyses uncover mitogenome features and phylogenetic implications of the subfamily Cobitinae.BMC genomics · 2021Article
- 5'-End sequencing in Saccharomyces cerevisiae offers new insights into 5'-ends of tRNAFEBS letters · 2019Article
- Pathways to disease from natural variations in human cytoplasmic tRNAs.The Journal of biological chemistry · 2019Review
- Review
- A Temporal Order in 5'- and 3'- Processing of Eukaryotic tRNAInternational journal of molecular sciences · 2019Article
- Adenosine to inosine mRNA editing in fungi and how it may relate to fungal pathogenesis.PLoS pathogens · 2018Review
- Review
- Human BCDIN3D Is a Cytoplasmic tRNAFrontiers in genetics · 2018Review
- Identification of distinct biological functions for four 3'-5' RNA polymerases.Nucleic acids research · 2016Article
- Novel modes of RNA editing in mitochondria.Nucleic acids research · 2016Article
- The transcriptome of Candida albicans mitochondria and the evolution of organellar transcription units in yeasts.BMC genomics · 2015Article
- NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs.RNA (New York, N.Y.) · 2015Article
- Large gene overlaps and tRNA processing in the compact mitochondrial genome of the crustacean Armadillidium vulgare.RNA biology · 2015Article
- Controlling translation via modulation of tRNA levels.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
During maturation, tRNA molecules undergo a series of individual processing steps, ranging from exo- and endonucleolytic trimming reactions at their 5'- and 3'-ends, specific base modifications and intron removal to the addition of the conserved 3'-terminal CCA sequence. Especially in mitochondria, this plethora of processing steps is completed by various editing events, where base identities at internal positions are changed and/or nucleotides at 5'- and 3'-ends are replaced or incorporated. In this review, we will focus predominantly on the latter reactions, where a growing number of cases indicate that these editing events represent a rather frequent and widespread phenomenon. While the mechanistic basis for 5'- and 3'-end editing differs dramatically, both reactions represent an absolute requirement for generating a functional tRNA. Current in vivo and in vitro model systems support a scenario in which these highly specific maturation reactions might have evolved out of ancient promiscuous RNA polymerization or quality control systems.
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