Evidence map›Paper›PMID 25535075›Full record

ReviewInternational journal of molecular sciences2014

The role of reactive oxygen species in microvascular remodeling.

Marius C Staiculescu, Christopher Foote, Gerald A Meininger, Luis A Martinez-Lemus

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Ying and Yang of Ceramide in the Vascular Endothelium.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Vascular mechanotransduction.Physiological reviews · 2023
    Review
  17. Involvement of AGE and Its Receptors in the Pathogenesis of Hypertension in Elderly People and Its Treatment.The International journal of angiology : official publication of the International College of Angiology, Inc · 2022
    Article
  18. Age-Related Changes in Skeletal Muscle Oxygen Utilization.Journal of functional morphology and kinesiology · 2022
    Review
  19. Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes.International journal of molecular sciences · 2022
    Review
  20. Healthberry 865Nutrients · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marius C StaiculescuDalton Cardiovascular Research Center, and Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA. mstaiculescu@seas.wustl.edu.
Christopher FooteDalton Cardiovascular Research Center, and Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA. footec@missouri.edu.
Gerald A MeiningerDalton Cardiovascular Research Center, and Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA. meiningerg@missouri.edu.
Luis A Martinez-LemusDalton Cardiovascular Research Center, and Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA. martinezlemusl@missouri.edu.
University of Missouri · US

Funding

Regulation Microvascular: Smooth Muscle Contraction ECM-Integrin-CytoskeletalP01HL095486 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, GEORGE E · 2010 to 2014
$8.4M
Mechanisms of Microvascular Remodeling ProgressionR01HL088105 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI MARTINEZ-LEMUS, LUIS A · 2009 to 2019
$3.3M
NHLBI NIH HHS P01 HL095486NHLBI NIH HHS R01 HL088105
6 · The paper itself

Abstract

The microcirculation is a portion of the vascular circulatory system that consists of resistance arteries, arterioles, capillaries and venules. It is the place where gases and nutrients are exchanged between blood and tissues. In addition the microcirculation is the major contributor to blood flow resistance and consequently to regulation of blood pressure. Therefore, structural remodeling of this section of the vascular tree has profound implications on cardiovascular pathophysiology. This review is focused on the role that reactive oxygen species (ROS) play on changing the structural characteristics of vessels within the microcirculation. Particular attention is given to the resistance arteries and the functional pathways that are affected by ROS in these vessels and subsequently induce vascular remodeling. The primary sources of ROS in the microcirculation are identified and the effects of ROS on other microcirculatory remodeling phenomena such as rarefaction and collateralization are briefly reviewed.

Indexed as

AnimalsHumansMicrocirculationMicrovesselsMuscle, Smooth, VascularMyocytes, Smooth MuscleNeovascularization, PathologicNeovascularization, PhysiologicReactive Oxygen SpeciesReactive Oxygen Species

Identifiers

PMID25535075
PMCPMC4284792
OpenAlexW2020759970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.