Evidence map›Paper›PMID 25534722›Full record

ArticleAntimicrobial agents and chemotherapy2015

Fidaxomicin therapy in critically ill patients with Clostridium difficile infection.

Samuel Penziner, Yanina Dubrovskaya, Robert Press, Amar Safdar

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Doctor, my patient has CDI and should continue to receive antibiotics. The (unresolved) risk of recurrent CDI.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2019
    Review
  5. [Recommendations from a panel of experts on the usefulness of fidaxomicin for the treatment of infections caused by Clostridium difficile].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2019
    Article
  6. Oral teicoplanin versus oral vancomycin for the treatment of severe Clostridium difficile infection: a prospective observational study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Observational
  7. Review
  8. Article
  9. Infections in Cancer Patients with Solid Tumors: A Review.Infectious diseases and therapy · 2017
    Review
  10. The efficacy of fidaxomicin in the treatment of Clostridium difficile infection in a real-world clinical setting: a Spanish multi-centre retrospective cohort.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Fidaxomicin: A novel agent for the treatment of Clostridium difficile infection.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samuel PenzinerNew York University Langone Medical Center and New York University School of Medicine, New York, New York.
Yanina DubrovskayaNew York University Langone Medical Center and New York University School of Medicine, New York, New York.
Robert PressNew York University Langone Medical Center and New York University School of Medicine, New York, New York.
Amar SafdarNew York University Langone Medical Center and New York University School of Medicine, New York, New York amar.safdar@nyumc.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fidaxomicin use to treat proven Clostridium difficile infection (CDI) was compared between 20 patients receiving care in critical care units (CCUs) and 30 patients treated on general medical floors. At baseline, the CCU patients had more initial CDI episodes, more severe and complicated disease, and more concurrent broad-spectrum antibiotic coverage. On multivariate analysis, the response to fidaxomicin therapy among the critically ill patients was comparable to that among patients in the general medical wards.

Indexed as

AminoglycosidesAnti-Bacterial AgentsClostridioides difficileClostridium InfectionsCritical IllnessFemaleFidaxomicinHumansMaleMiddle AgedPatients' RoomsAminoglycosidesAnti-Bacterial AgentsFidaxomicin

Identifiers

PMID25534722
PMCPMC4325788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.