ReviewNature reviews. Immunology2015
Periodontitis: from microbial immune subversion to systemic inflammation.
Review in Nature reviews. Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 1,581 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of a Molecular Diagnosing Platform for Monitoring Oral Hygiene in Diabetic Patients
Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)
The Effect of Non-surgical Periodontal Treatment on the Biomechanical Properties of the Periodontal Tissues, a Prospective Comparative Clinical Trial.
Clinical Evaluation of a Mouthwash Containing Malva Sylvestris Extract and Its Role in Reducing Oral Biofilm and Gingival Inflammation. A Randomized, Triple Masked Clinical Trial.
Can Delta Neutrophil Index Values Predict the Success of Periodontal Treatment in Patients With Periodontitis?
Clinical and Laboratory Evaluation of Resveratrol Loaded Nanoparticles in the Treatment of Periodontitis: A Randomized Controlled Clinical Trial
Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy
Effect of Preoperative Periodontal Treatment on Postoperative Infection and Mortality in Patients Undergoing Aortic and Mitral Valve Surgery: A Retrospective Study
Who cites it
1,581 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- The Impact of Periodontal Health Interventions on the Risk of Ischemic Stroke: A Systematic Review and Meta-Analysis.International journal of dental hygiene · 2026Pooled it
- Natural Agents for the Improvement of Gingival Health: Systematic Review and Meta-Analysis of Randomized Clinical Trials.Oral health & preventive dentistry · 2026Pooled it
- Local curcumin/turmeric-derived delivery adjunctive to scaling and root planing for periodontitis: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Artificial Intelligence in Periodontology: A Systematic Review.Journal of periodontal research · 2026Pooled it
- The impact of periodontitis on physical fitness: a systematic review.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2026Pooled it
- Association of Crohn's disease with periodontal disease risk and severity: a meta-analytic study.Acta odontologica Scandinavica · 2026Pooled it
- Decoding the periodontitis-coronary artery disease axis through biomarker profiling: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Age-Related Differences in Oral Microbiota Among Obese Patients with Periodontitis: A Systematic Review.Nutrients · 2026Pooled it
- Do Adjunctive Therapies with Natural Products Improve Periodontal Clinical Parameters After Non-Surgical Treatment? A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- Association between periodontal disease and prostatic disease: a systematic review and meta-analysis of observational studies.The Canadian journal of urology · 2026Pooled it
- Effects of non-surgical periodontal therapy on prostate-specific antigen levels and recurrent urinary tract infections: a randomized controlled clinical study.Scientific reports · 2026Trial
- Electrolyzed saline as an alternative to chlorhexidine: Antimicrobial and biofilm volume outcomes in a 4-day non-brushing randomized controlled clinical trial.Journal of periodontology · 2026Trial
- A randomized controlled trial of home-applied dual-light photodynamic therapy during supportive periodontal care (HOPE-CP study).Journal of periodontology · 2026Trial
- The role of the oxytocinergic system in oral microbiome composition in children with autism: evidence from a randomized controlled trial of intranasal oxytocin.Translational psychiatry · 2026Trial
- An oxygen-releasing mouthwash shows species-dependent antibacterial and antibiofilm activity against periodontal pathogens.Clinical oral investigations · 2026Article
- Adjunctive antimicrobial photodynamic therapy in the nonsurgical treatment of periodontitis: an umbrella review.BDJ open · 2026Review
- Diagnostic Accuracy of Salivary Thiols Point-of-Care Test for Detecting Subgingival Dysbiosis in Adults: A Cross-Sectional Study.Clinical and experimental dental research · 2026Article
- Strontium-incorporated thermoresponsive hydrogel platform co-delivering graphene oxide-mannose nanocomplexes: An osteoimmunomodulatory strategy for periodontitis therapy.Materials today. Bio · 2026Article
- Bioorthogonal aggregation-induced emission nanoprobes for targeted photodynamic eradication of Gram-negative pathogens in periodontitis.Materials today. Bio · 2026Article
- The dynamic landscape of T helper cell plasticity and Th17-Treg instability in periodontitis.Experimental & molecular medicine · 2026Review
1,521 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Periodontitis is a dysbiotic inflammatory disease with an adverse impact on systemic health. Recent studies have provided insights into the emergence and persistence of dysbiotic oral microbial communities that can mediate inflammatory pathology at local as well as distant sites. This Review discusses the mechanisms of microbial immune subversion that tip the balance from homeostasis to disease in oral or extra-oral sites.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.