Evidence map›Paper›PMID 25534620›Full record

ReviewNature reviews. Immunology2015

Dendritic cell metabolism.

Edward J Pearce, Bart Everts

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 283 papers.

0numbers the graph read from it
0cells of the map it votes in
283citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

283 citing papers in PubMed, 472 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. The Role of Glucose Metabolism inInternational journal of molecular sciences · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
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  12. Review
  13. Review
  14. Review
  15. NasalJournal of inflammation research · 2026
    Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

223 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Edward J PearceDepartment of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Bart EvertsDepartment of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Leiden University Medical Center · NL

Funding

MANIPULATING DENDRITIC CELL METABOLISM TO PROMOTE CANCER IMMUNITYR01CA164062 · NCI · WASHINGTON UNIVERSITY · PI PEARCE, EDWARD J. · 2012 to 2016
$1.7M
NCI NIH HHS R01 CA164062
6 · The paper itself

Abstract

The past 15 years have seen enormous advances in our understanding of the receptor and signalling systems that allow dendritic cells (DCs) to respond to pathogens or other danger signals and initiate innate and adaptive immune responses. We are now beginning to appreciate that many of these pathways not only stimulate changes in the expression of genes that control DC immune functions, but also affect metabolic pathways, thereby integrating the cellular requirements of the activation process. In this Review, we focus on this relatively new area of research and attempt to describe an integrated view of DC immunometabolism.

Indexed as

AnimalsDendritic CellsHumansImmunity, InnateIntracellular SpaceMitochondriaSignal Transduction

Identifiers

PMID25534620
PMCPMC4495583
OpenAlexW2088402590

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.