ReviewBrain pathology (Zurich, Switzerland)2015
Primary melanocytic tumors of the central nervous system: a review with focus on molecular aspects.
Review in Brain pathology (Zurich, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05984108 (Clinical, Radiological, Histological and Molecular Features of a Cohort of Melanocytic Tumors of the Central Nervous System), which is not on this map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical, Radiological, Histological and Molecular Features of a Cohort of Melanocytic Tumors of the Central Nervous System
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- Impact of chemotherapy and immunotherapy on survival in pediatric primary diffuse leptomeningeal melanomatosis: a systematic review and pooled survival analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
- Enhancement of the leptomeninges in a young man.Brain pathology (Zurich, Switzerland) · 2026Article
- Amelanotic primary thalamic melanoma: a case report.BMC neurology · 2026Article
- Pediatric Primary Diffuse Leptomeningeal Melanomatosis: A Case Report and Literature Review.Cureus · 2026Article
- Severe cord compression due to unique extradural meningeal melanocytoma of intermediate grade.Surgical neurology international · 2026Article
- Primary amelanotic leptomeningeal melanocytosis mimicking subarachnoid hemorrhage: a case report of the deceptive masquerader.Frontiers in oncology · 2026Article
- Overall survival following treatment of central nervous system meningeal melanocytomas: Insights from the national cancer database (NCDB).Brain & spine · 2026Article
- A T1-isointense meningeal melanocytoma mimicking meningioma: Case report and literature review.Radiology case reports · 2025Article
- Article
- Primary Intramedullary Spinal Melanocytomas: Case Report and Review of Clinical Features, Diagnosis, and Management.Journal of clinical medicine · 2025Review
- Primary Intracranial Meningeal Melanocytoma with Malignant Transformation: A Case Report and Comparison of Early Versus Late Immunotherapy Interventions.Current oncology (Toronto, Ont.) · 2025Article
- Aggressive Clinical Course and Malignant Transformation of a Meningeal Melanocytoma of the Pontomedullary Region: Diagnostic and Therapeutic Implications.Journal of neurological surgery reports · 2025Article
- Roles of Peripheral Nerves in Tumor Initiation and Progression.International journal of molecular sciences · 2025Review
- Pigmented Peril: A fatal case of Primary intracranial melanoma in a paediatric patient.Radiology case reports · 2025Article
- Freiburg Neuropathology Case Conference: Gait Ataxia, Segmental Hypoesthesia, and Combined Incontinence in a 57-Years-Old Patient.Clinical neuroradiology · 2025Article
- Meningeal melanocytoma of the central nervous system in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- A rare case report of primary malignant melanocytoma of foramen magnum and literature review.Surgical neurology international · 2025Article
- he Dark Corner of the Pituitary Gland: A Case Report and Literature Review of Primary MelanocytomaCurrent medical imaging · 2025Review
- GNAQ/GNA11-Related Benign and Malignant Entities-A Common Histoembriologic Origin or a Tissue-Dependent Coincidence.Cancers · 2024Review
- The 2023 WHO updates on skin tumors: advances since the 2018 edition.Pathologica · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary melanocytic tumors of the central nervous system (CNS) represent a spectrum of rare tumors. They can be benign or malignant and occur in adults as well as in children, the latter often in the context of neurocutaneous melanosis. Until recently, the genetic alterations in these tumors were largely unknown. This is in contrast with cutaneous and uveal melanomas, which are known to harbor distinct oncogenic mutations that can be used as targets for treatment with small-molecule inhibitors in the advanced setting. Recently, novel insights in the molecular alterations underlying primary melanocytic tumors of the CNS were obtained, including different oncogenic mutations in tumors in adult patients (especially GNAQ, GNA11) vs. children (especially NRAS). In this review, the focus is on molecular characteristics of primary melanocytic tumors of the CNS. We summarize what is known about their genetic alterations and discuss implications for pathogenesis and differential diagnosis with other pigmented tumors in or around the CNS. Finally, new therapeutic options with targeted therapy are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.