ArticleEnvironmental health : a global access science source2014
A path forward in the debate over health impacts of endocrine disrupting chemicals.
Article in Environmental health : a global access science source, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Endocrine Disrupting Chemicals in Human Milk: A Systematic Review of Concentrations and Potential Health Implications.Current environmental health reports · 2025Pooled it
- A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals.Environmental health : a global access science source · 2016Pooled it
- Using systematic reviews for hazard and risk assessment of endocrine disrupting chemicals.Reviews in endocrine & metabolic disorders · 2015Pooled it
- Review
- The ethical and social significance of NAM terminology and definitions.NAM journal · 2026Article
- Pesticides, an urgent challenge to global environmental health and planetary boundaries.Frontiers in toxicology · 2025Review
- Words Matter: Reflective Science Communication and Tradeoffs in Environmental Health Research.Environmental health perspectives · 2024Article
- Thresholds of adversity for endocrine disrupting substances: a conceptual case study.Archives of toxicology · 2024Article
- Science evolves but outdated testing and static risk management in the US delay protection to human health.Frontiers in toxicology · 2024Article
- The regulation of endocrine-disrupting chemicals to minimize their impact on health.Nature reviews. Endocrinology · 2023Review
- Evaluating adverse effects of environmental agents in food: a brief critique of the US FDA's criteria.Environmental health : a global access science source · 2023Review
- An Analysis of the Structural Relationship between Thyroid Hormone-Signaling Disruption and Polybrominated Diphenyl Ethers: Potential Implications for Male Infertility.International journal of molecular sciences · 2023Article
- Endocrine disruptors of sex hormone activities.Molecular and cellular endocrinology · 2022Review
- REPRODUCTIVE TOXICOLOGY: Endocrine disruption and reproductive disorders: impacts on sexually dimorphic neuroendocrine pathways.Reproduction (Cambridge, England) · 2021Review
- Impact of Estrogen Withdrawal and Replacement in Female Mice along the Intestinal Tract. Comparison of E2 Replacement with the Effect of a Mixture of Low Dose Pollutants.International journal of environmental research and public health · 2021Article
- Exogenous Factors Affecting the Functional Integrity of Male Reproduction.Life (Basel, Switzerland) · 2021Review
- Update on the Health Effects of Bisphenol A: Overwhelming Evidence of Harm.Endocrinology · 2021Review
- Assessing the Public Health Implications of the Food Preservative Propylparaben: Has This Chemical Been Safely Used for Decades.Current environmental health reports · 2021Review
- Review
- Endocrine disrupting chemicals in the pathogenesis of hypospadias; developmental and toxicological perspectives.Current research in toxicology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several recent publications reflect debate on the issue of "endocrine disrupting chemicals" (EDCs), indicating that two seemingly mutually exclusive perspectives are being articulated separately and independently. Considering this, a group of scientists with expertise in basic science, medicine and risk assessment reviewed the various aspects of the debate to identify the most significant areas of dispute and to propose a path forward. We identified four areas of debate. The first is about the definitions for terms such as "endocrine disrupting chemical", "adverse effects", and "endocrine system". The second is focused on elements of hormone action including "potency", "endpoints", "timing", "dose" and "thresholds". The third addresses the information needed to establish sufficient evidence of harm. Finally, the fourth focuses on the need to develop and the characteristics of transparent, systematic methods to review the EDC literature. Herein we identify areas of general consensus and propose resolutions for these four areas that would allow the field to move beyond the current and, in our opinion, ineffective debate.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.