Evidence map›Paper›PMID 25533643›Full record

ArticleJournal of behavioral medicine2015

Depressive symptoms and spiritual wellbeing in asymptomatic heart failure patients.

Paul J Mills, Kathleen Wilson, Navaid Iqbal, Fatima Iqbal, Milagros Alvarez, Meredith A Pung, Katherine Wachmann, Thomas Rutledge, Jeanne Maglione, Sid Zisook and 9 more

Abstract read
In one paragraph

Article in Journal of behavioral medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
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  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Paul J MillsDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Dr. #0804, La Jolla, CA, 92093-0804, USA, pmills@ucsd.edu.
Kathleen Wilson
Navaid Iqbal
Fatima Iqbal
Milagros Alvarez
Meredith A Pung
Katherine Wachmann
Thomas Rutledge
Jeanne Maglione
Sid Zisook
Joel E Dimsdale
Ottar Lunde
Barry H Greenberg
Alan Maisel
Ajit Raisinghani
Loki Natarajan
Shamini Jain
David J Hufford
Laura Redwine

Funding

ZOVIRAX CREAM TO TREAT HERPES LABIALIS IN ADOLESCENTSM01RR000827 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZELL, JASON · 1985 to 2010
$74.3M
San Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7M
FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
BNP and Neuroimmune Characteristics of CHF &DepressionR01HL073355 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLS, PAUL J · 2005 to 2014
$5.6M
Exploring Tai Chi as a Behavioral Intervention for Heart Failure PatientsR01HL096784 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI REDWINE, LAURA S · 2010 to 2013
$1.5M
NCATS NIH HHS 5UL1 TR000100-05NCATS NIH HHS UL1 TR000100NCRR NIH HHS M01 RR000827NHLBI NIH HHS HL-073355NHLBI NIH HHS HL-096784NHLBI NIH HHS R01 HL073355NHLBI NIH HHS R01 HL096784NIMH NIH HHS T32 MH019934
6 · The paper itself

Abstract

Depression adversely predicts prognosis in individuals with symptomatic heart failure. In some clinical populations, spiritual wellness is considered to be a protective factor against depressive symptoms. This study examined associations among depressive symptoms, spiritual wellbeing, sleep, fatigue, functional capacity, and inflammatory biomarkers in 132 men and women with asymptomatic stage B heart failure (age 66.5 years ± 10.5). Approximately 32 % of the patients scored ≥10 on the Beck Depression Inventory, indicating potentially clinically relevant depressive symptoms. Multiple regression analysis predicting fewer depressive symptoms included the following significant variables: a lower inflammatory score comprised of disease-relevant biomarkers (p < 0.02), less fatigue (p < 0.001), better sleep (p < 0.04), and more spiritual wellbeing (p < 0.01) (overall model F = 26.6, p < 0.001, adjusted R square = 0.629). Further analyses indicated that the meaning (p < 0.01) and peace (p < 0.01) subscales, but not the faith (p = 0.332) subscale, of spiritual wellbeing were independently associated with fewer depressive symptoms. Interventions aimed at increasing spiritual wellbeing in patients lives, and specifically meaning and peace, may be a potential treatment target for depressive symptoms asymptomatic heart failure.

Indexed as

Religion and PsychologySpiritualityActivities of Daily LivingAdultAgedBiomarkersDepressive DisorderFatigueFemaleHeart FailureHumansMaleMiddle AgedMultivariate AnalysisPersonality InventoryPsychiatric Status Rating ScalesBiomarkers

Identifiers

PMID25533643
PMCPMC4425583

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.