ArticleDiabetologia2015
Plasma isoflavone concentration is associated with decreased risk of type 2 diabetes in Korean women but not men: results from the Korean Genome and Epidemiology Study.
Article in Diabetologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Associations between Phytoestrogens, Glucose Homeostasis, and Risk of Diabetes in Women: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2018Pooled it
- Exploring the Health Effects of Phytoestrogens.Metabolites · 2026Review
- Associations between dietary isoflavones and subtypes intakes and the risk of new-onset of type 2 diabetes mellitus in Chinese adults: a prospective cohort study from the Chinese health and nutrition survey.Frontiers in nutrition · 2026Article
- The Translational Coupling of Daidzein Reductase and Dihydrodaidzein Racemase Genes Improves the Production of Equol and Its Analogous Derivatives in Engineered Lactic Acid Bacteria.ACS synthetic biology · 2025Article
- Promoting cognitive health through the nexus of gut microbiota and dietary phytochemicals.Frontiers in nutrition · 2025Review
- Equol Nonproducing Status as an Independent Risk Factor for Acute Cardioembolic Stroke and Poor Functional Outcome.Nutrients · 2024Article
- Effect of Fermented Soy Beverage on Equol Production by Fecal Microbiota.Foods (Basel, Switzerland) · 2024Article
- Nutraceuticals as Supportive Therapeutic Agents in Diabetes and Pancreatic Ductal Adenocarcinoma: A Systematic Review.Biology · 2023Review
- Gene-diet interaction analysis using novel weighted food scores discovers the adipocytokine signaling pathway associated with the development of type 2 diabetes.Frontiers in endocrinology · 2023Article
- Phenolic Profiles and Bioactivities of Ten Original Lineage Beans in Thailand.Foods (Basel, Switzerland) · 2022Article
- Miso: A traditional nutritious & health-endorsing fermented product.Food science & nutrition · 2022Review
- Genistein-Opportunities Related to an Interesting Molecule of Natural Origin.Molecules (Basel, Switzerland) · 2022Review
- Gut Microbiota in Bone Health and Diabetes.Current osteoporosis reports · 2021Review
- The Role of Isoflavones in Type 2 Diabetes Prevention and Treatment-A Narrative Review.International journal of molecular sciences · 2020Review
- Scientific Evidence Supporting the Beneficial Effects of Isoflavones on Human Health.Nutrients · 2020Review
- Association between dietary sodium intake and disease burden and mortality in Koreans between 1998 and 2016: The Korea National Health and Nutrition Examination Survey.Nutrition research and practice · 2020Article
- Urinary equol, but not daidzein and genistein, was inversely associated with the risk of type 2 diabetes in Chinese adults.European journal of nutrition · 2020Article
- Article
- Effect of S-equol and Soy Isoflavones on Heart and Brain.Current cardiology reviews · 2019Review
- Serum metabolite profile associated with incident type 2 diabetes in Koreans: findings from the Korean Genome and Epidemiology Study.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisTo examine the association between soybean products and risk of type 2 diabetes, we measured four isoflavone biological markers--genistein, daidzein, glycitein and equol--in a nested case-control study.
methodsThe study population was composed of 693 cases (316 women and 377 men) and 698 matched controls (317 women and 381 men) within the Korean Genome and Epidemiology Study. The concentrations of isoflavone biomarkers were measured using HPLC-MS/MS on plasma samples that were collected at baseline. A stratified analysis was undertaken to examine the association between plasma isoflavone concentrations and risk of type 2 diabetes according to sex and equol production. Logistic regression models were used to compute ORs and 95% CIs adjusted for confounders.
resultsIn women, compared with the lowest quartile of plasma concentration of genistein, the highest quartile exhibited a significantly decreased risk of diabetes (OR 0.58, 95% CI 0.35, 0.95). When stratified by equol-producing status in women, the OR for diabetes in the highest vs the lowest quartile of genistein concentration was 0.31 (95% CI 0.16, 0.60) in equol producers, but genistein concentration was not associated with risk of diabetes in equol non-producers (p for interaction = 0.013). In men, isoflavone concentrations were not associated with risk of diabetes, regardless of equol-producing status. CONCLUSIONS/
interpretationHigh plasma concentrations of genistein were associated with a decreased risk of type 2 diabetes in women. This inverse association was prominent in equol-producing participants. These results suggest a beneficial effect of a high intake of soybean products on risk of type 2 diabetes in women.
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