ArticleCell reports2014
Channelrhodopsin-assisted patching: in vivo recording of genetically and morphologically identified neurons throughout the brain.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Optogenetic Mapping of Rhythmic Phase-Dependent Excitability in the Mouse Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Local stimulation of pyramidal neurons in deep cortical layers of anesthetized rats enhances cortical visual information processing.Scientific reports · 2024Article
- In Vivo Whole-Cell Recording from the Mouse Brain.Methods in molecular biology (Clifton, N.J.) · 2024Article
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- Opto-juxtacellular interrogation of neural circuits in freely moving mice.Nature protocols · 2023Review
- Cell-type-specific propagation of visual flicker.Cell reports · 2023Article
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- Automated microscope-independent fluorescence-guided micropipette.Biomedical optics express · 2021Article
- In Vivo Whole-Cell Patch-Clamp Methods: Recent Technical Progress and Future Perspectives.Sensors (Basel, Switzerland) · 2021Review
- Magnetically guided virus stamping for the targeted infection of single cells or groups of cells.Nature protocols · 2019Article
- Recruitment of GABAergic Interneurons in the Barrel Cortex during Active Tactile Behavior.Neuron · 2019Article
- Dynamics of Neuronal Activity in the Cortical Column during Behavior: Both Neuron Type and Layers Matter.Neuron · 2019Article
- Diversity and Function of Somatostatin-Expressing Interneurons in the Cerebral Cortex.International journal of molecular sciences · 2019Review
- Complementary networks of cortical somatostatin interneurons enforce layer specific control.eLife · 2019Article
- Superficial Layers Suppress the Deep Layers to Fine-tune Cortical Coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Four Unique Interneuron Populations Reside in Neocortical Layer 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Flexible Nanopipettes for Minimally Invasive Intracellular Electrophysiology In Vivo.Cell reports · 2019Article
- Article
- Distribution Patterns of Three Molecularly Defined Classes of GABAergic Neurons Across Columnar Compartments in Mouse Barrel Cortex.Frontiers in neuroanatomy · 2019Article
- Optogenetics Identification of a Neuronal Type with a Glass Optrode in Awake Mice.Journal of visualized experiments : JoVE · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Brain networks contain a large diversity of functionally distinct neuronal elements, each with unique properties, enabling computational capacities and supporting brain functions. Understanding their functional implications for behavior requires the precise identification of the cell types of a network and in vivo monitoring of their activity profiles. Here, we developed a channelrhodopsin-assisted patching method allowing the efficient in vivo targeted recording of neurons identified by their molecular, electrophysiological, and morphological features. The method has a high yield, does not require visual guidance, and thus can be applied at any depth in the brain. This approach overcomes limitations of present technologies. We validate this strategy with in vivo recordings of identified subtypes of GABAergic and glutamatergic neurons in deep cortical layers, subcortical cholinergic neurons, and neurons in the thalamic reticular nucleus in anesthetized and awake mice. We propose this method as an important complement to existing technologies to relate specific cell-type activity to brain circuitry, function, and behavior.
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Registered trials
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