ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Genetic context modulates aging and degeneration in the murine retina.Molecular neurodegeneration · 2025Article
- Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model.PloS one · 2025Article
- Genetic context modulates aging and degeneration in the murine retina.bioRxiv : the preprint server for biology · 2024Article
- Unsupervised learning of aging principles from longitudinal data.Nature communications · 2022Article
- Single nucleotide polymorphism patterns associated with a cancer resistant phenotype.Experimental and molecular pathology · 2022Article
- Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.Aging cell · 2020Article
- A toolbox for the longitudinal assessment of healthspan in aging mice.Nature protocols · 2020Article
- Genetic Support for Longevity-Enhancing Drug Targets: Issues, Preliminary Data, and Future Directions.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Review
- Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass.PLoS genetics · 2019Article
- Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.GeroScience · 2019Review
- Computational tools for geroscience.Translational medicine of aging · 2019Article
- Identifying and Implementing Endpoints for Geriatric Mice.Comparative medicine · 2018Article
- Genetic cartography of longevity in humans and mice: Current landscape and horizons.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- Reproducibility and replicability of rodent phenotyping in preclinical studies.Neuroscience and biobehavioral reviews · 2018Review
- Oral health in geroscience: animal models and the aging oral cavity.GeroScience · 2018Review
- Translational Geroscience: From invertebrate models to companion animal and human interventions.Translational medicine of aging · 2018Article
- Article
- PDE11A negatively regulates lithium responsivity.Molecular psychiatry · 2017Article
- Unique sex- and age-dependent effects in protective pathways in acute kidney injury.American journal of physiology. Renal physiology · 2017Article
- MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Understanding the source of genetic variation in aging and using this variation to define the molecular mechanisms of healthy aging require deep and broad quantification of a host of physiological, morphological, and behavioral endpoints. The murine model is a powerful system in which to understand the relations across age-related phenotypes and to identify research models with variation in life span and health span. The Jackson Laboratory Nathan Shock Center of Excellence in the Basic Biology of Aging has performed broad characterization of aging in genetically diverse laboratory mice and has placed these data, along with data from several other major aging initiatives, into the interactive Mouse Phenome Database. The data may be accessed and analyzed by researchers interested in finding mouse models for specific aging processes, age-related health and disease states, and for genetic analysis of aging variation and trait covariation. We expect that by placing these data in the hands of the aging community that there will be (a) accelerated genetic analyses of aging processes, (b) discovery of genetic loci regulating life span, (c) identification of compelling correlations between life span and susceptibility for age-related disorders, and (d) discovery of concordant genomic loci influencing life span and aging phenotypes between mouse and humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.