Evidence map›Paper›PMID 25533276›Full record

Trial reportClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2015

Inter-session reliability of electrical impedance myography in children in a clinical trial setting.

Tom R Geisbush, Nicole Visyak, Lavanya Madabusi, Seward B Rutkove, Basil T Darras

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Reliability of bioimpedance spectroscopy in the upper trapezius muscle.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2026
    Article
  2. Review
  3. Article
  4. Article
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  7. Exploring the relationship between electrical impedance myography and quantitative ultrasound parameters in Duchenne muscular dystrophy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tom R GeisbushDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Nicole VisyakBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Lavanya MadabusiBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Seward B RutkoveDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: srutkove@bidmc.harvard.edu.
Basil T DarrasBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Boston Children's Hospital · USBeth Israel Deaconess Medical Center · USHarvard University · US

Funding

Electrical impedance myography and quantitative ultrasound in Duchenne muscular dR01AR060850 · NIAMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DARRAS, BASIL T, RUTKOVE, SEWARD B. · 2011 to 2014
$1.7M
NIAMS NIH HHS R01 AR060850NIAMS NIH HHS R01AR060850
6 · The paper itself

Abstract

objectiveHigh reliability is a prerequisite for any test to be useful as a biomarker in a clinical trial. Here we assessed the reproducibility of electrical impedance myography (EIM) in children by comparing data obtained by different evaluators on separate days.

methodsHealthy boys and boys with Duchenne muscular dystrophy (DMD) aged 2-14 years underwent EIM of multiple muscles performed by two evaluators on two visits separated by 3-7 days. Single and multifrequency data were analyzed. Reliability was assessed via calculation of the percent relative standard deviation (% RSD), Bland-Altman analysis, and the intraclass correlation coefficient (ICC).

resultsFor both individual muscle data and data averaged across muscles, intra-evaluator measurements showed high repeatability for both 50 kHz phase and 50/200 kHz phase ratio values, with ICCs generally above 0.90 and % RSD below 10%. Inter-evaluator results showed very similar ICC and % RSD values as those obtained by the same evaluator.

conclusionsBoth the 50 kHz phase and 50/200 kHz phase ratio are reliable measures both across time and evaluators and in both health and disease. SIGNIFICANCE: These results support the concept that EIM can serve as a reliable measure in clinical therapeutic trials in a pediatric population.

Indexed as

AdolescentChildChild, PreschoolElectric ImpedanceElectromyographyFemaleHumansMaleMuscular Dystrophy, DuchenneMyographyReproducibility of ResultsDuchenne muscular dystrophyElectrical impedance myographyReliability measures

Identifiers

PMID25533276
PMCPMC4447621
OpenAlexW2080403802

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.