ReviewNutrients2014
Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight.
Review in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Trial
- Lifestyle factors in hepatocellular carcinoma: From pathogenesis to prognosis.World journal of clinical oncology · 2025Review
- Examining associations of digestive system cancer with hypertension and diabetes using network analysis in older patients.Scientific reports · 2025Article
- Diabetes risk reduction diet and risk of liver cancer and chronic liver disease mortality: A prospective cohort study.Journal of internal medicine · 2024Observational
- Substitutability of nicotine and sucrose in rats: A behavioral economic analysis.Pharmacology, biochemistry, and behavior · 2023Article
- Article
- Understanding the Link between Sugar and Cancer: An Examination of the Preclinical and Clinical Evidence.Cancers · 2022Review
- Chronic liquid fructose supplementation does not cause liver tumorigenesis but elicits clear sex differences in the metabolic response in Sprague-Dawley rats.Food & nutrition research · 2021Article
- Diet and Risk of Myeloproliferative Neoplasms in Older Individuals from the NIH-AARP Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Persistent changes in liver methylation and microbiome composition following reversal of diet-induced non-alcoholic-fatty liver disease.Cellular and molecular life sciences : CMLS · 2019Article
- A new method to induce nonalcoholic steatohepatitis (NASH) in mice.BMC gastroenterology · 2019Article
- Sugary drink consumption and risk of cancer: results from NutriNet-Santé prospective cohort.BMJ (Clinical research ed.) · 2019Observational
- Chronic fructose intake does not induce liver steatosis and inflammation in female Sprague-Dawley rats, but causes hypertriglyceridemia related to decreased VLDL receptor expression.European journal of nutrition · 2019Article
- Waist circumference is a mediator of dietary pattern in Non-alcoholic fatty liver disease.Scientific reports · 2018Article
- Development of hepatocellular cancer induced by long term low fat-high carbohydrate diet in a NAFLD/NASH mouse model.Oncotarget · 2017Article
- Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide.Scientific reports · 2017Article
- Carrot Juice Administration Decreases Liver Stearoyl-CoA Desaturase 1 and Improves Docosahexaenoic Acid Levels, but Not Steatosis in High Fructose Diet-Fed Weanling Wistar Rats.Preventive nutrition and food science · 2016Article
- Glucose induced activation of canonical Wnt signaling pathway in hepatocellular carcinoma is regulated by DKK4.Scientific reports · 2016Article
- The effects of nicotine self-administration and withdrawal on concurrently available chow and sucrose intake in adult male rats.Physiology & behavior · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sugar intake has dramatically increased during the last few decades. Specifically, there has been a clear trend towards higher consumption of fructose and high fructose corn syrup, which are the most common added sugars in processed food, soft drinks and other sweetened beverages. Although still controversial, this rising trend in simple sugar consumption has been positively associated with weight gain and obesity, insulin resistance and type 2 diabetes mellitus and non-alcoholic fatty liver disease. Interestingly, all of these metabolic alterations have also been related to the development of hepatocellular carcinoma. The purpose of this review is to discuss the evidence coming from epidemiological studies and data from animal models relating the consumption of simple sugars, and specifically fructose, with an increased risk of hepatocellular carcinoma and to gain insight into the putative molecular mechanisms involved.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.