ArticleBipolar disorders2015
Age-associated alterations in corpus callosum white matter integrity in bipolar disorder assessed using probabilistic tractography.
Article in Bipolar disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- White Matter Tract Alterations in Bipolar Disorder: A Systematic Review and Meta-Analysis of Diffusion Tensor Imaging Studies.Brain and behavior · 2026Pooled it
- Brain White Matter Microstructure in Middle and Older Aged Adults With Bipolar Disorder: A 2-Site Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Distinguished Frontal White Matter Abnormalities Between Psychotic and Nonpsychotic Bipolar Disorders in a Pilot Study.Brain sciences · 2025Article
- Shared and distinct white matter abnormalities in adolescent-onset schizophrenia and adolescent-onset psychotic bipolar disorder.Psychological medicine · 2023Article
- Altered Levels of Plasma Inflammatory Cytokines and White Matter Integrity in Bipolar Disorder Patients With Suicide Attempts.Frontiers in psychiatry · 2022Article
- Age-related white matter changes revealed by a whole-brain fiber-tracking method in bipolar disorder compared to major depressive disorder and healthy controls.Psychiatry and clinical neurosciences · 2021Article
- White matter correlates of cognitive flexibility in youth with bipolar disorder and typically developing children and adolescents.Psychiatry research. Neuroimaging · 2020Article
- Age-Related Alterations of White Matter Integrity in Adolescents and Young Adults With Bipolar Disorder.Frontiers in psychiatry · 2019Article
- Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder.BMC psychiatry · 2018Article
- Preliminary mapping of the structural effects of age in pediatric bipolar disorder with multimodal MR imaging.Psychiatry research. Neuroimaging · 2018Article
- Physical activity is associated with left corticospinal tract microstructure in bipolar depression.NeuroImage. Clinical · 2018Article
- Steeper Slope of Age-Related Changes in White Matter Microstructure and Processing Speed in Bipolar Disorder.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
- Limited Evidence for Association of Genome-Wide Schizophrenia Risk Variants on Cortical Neuroimaging Phenotypes.Schizophrenia bulletin · 2016Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
objectivesAtypical age-associated changes in white matter integrity may play a role in the neurobiology of bipolar disorder, but no studies have examined the major white matter tracts using nonlinear statistical modeling across a wide age range in this disorder. The goal of this study was to identify possible deviations in the typical pattern of age-associated changes in white matter integrity in patients with bipolar disorder across the age range of 9-62 years.
methodsDiffusion tensor imaging was performed in 57 (20 male and 37 female) patients with a diagnosis of bipolar disorder and 57 (20 male and 37 female) age- and sex-matched healthy volunteers. Mean diffusivity and fractional anisotropy were computed for the genu and splenium of the corpus callosum, two projection tracts, and five association tracts using probabilistic tractography.
resultsOverall, patients had lower fractional anisotropy and higher mean diffusivity compared to healthy volunteers across all tracts (while controlling for the effects of age and age(2) ). In addition, there were greater age-associated increases in mean diffusivity in patients compared to healthy volunteers within the genu and splenium of the corpus callosum beginning in the second and third decades of life.
conclusionsOur findings provide evidence for alterations in the typical pattern of white matter development in patients with bipolar disorder compared to healthy volunteers. Changes in white matter development within the corpus callosum may lead to altered inter-hemispheric communication that is considered integral to the neurobiology of the disorder.
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