Evidence map›Paper›PMID 25532804›Full record

ArticleCell host & microbe2015

Diet dominates host genotype in shaping the murine gut microbiota.

Rachel N Carmody, Georg K Gerber, Jesus M Luevano, Daniel M Gatti, Lisa Somes, Karen L Svenson, Peter J Turnbaugh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 580 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
580citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

580 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Roles of the gut microbiome in weight management.Nature reviews. Microbiology · 2023
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Applied and environmental microbiology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. The island biology of the host microbiome.Trends in microbiology · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

520 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Rachel N CarmodyFAS Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA; Department of Microbiology and Immunology, Hooper Foundation, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Georg K GerberCenter for Clinical and Translational Metagenomics, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.
Jesus M LuevanoFAS Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.
Daniel M GattiThe Jackson Laboratory, 610 Main Street, Bar Harbor, ME 04609, USA.
Lisa SomesThe Jackson Laboratory, 610 Main Street, Bar Harbor, ME 04609, USA.
Karen L SvensonThe Jackson Laboratory, 610 Main Street, Bar Harbor, ME 04609, USA.
Peter J TurnbaughFAS Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA; Department of Microbiology and Immunology, Hooper Foundation, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address: peter.turnbaugh@ucsf.edu.

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI LYNN BRY · 1986 to 2026
$32.4M
UNC and PERLEGEN, IncP50GM076468 · NIGMS · JACKSON LABORATORY · PI CHESLER, ELISSA J · 2006 to 2015
$31.0M
THEORETICAL ANALYSIS OF FUNCTIONAL MODULESP50GM068763 · NIGMS · HARVARD UNIVERSITY · PI STERN, BODO · 2003 to 2012
$28.9M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Gut microbial promotion of energy gain from processed dietsF32DK101154 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CARMODY, RACHEL NAOMI · 2013 to 2016
$141k
NIDDK NIH HHS F32 DK101154NIDDK NIH HHS P30 DK034854NIDDK NIH HHS P30 DK063720NIGMS NIH HHS P50 GM068763NIGMS NIH HHS P50GM068763NIGMS NIH HHS P50 GM076468
6 · The paper itself

Abstract

Mammals exhibit marked interindividual variations in their gut microbiota, but it remains unclear if this is primarily driven by host genetics or by extrinsic factors like dietary intake. To address this, we examined the effect of dietary perturbations on the gut microbiota of five inbred mouse strains, mice deficient for genes relevant to host-microbial interactions (MyD88(-/-), NOD2(-/-), ob/ob, and Rag1(-/-)), and >200 outbred mice. In each experiment, consumption of a high-fat, high-sugar diet reproducibly altered the gut microbiota despite differences in host genotype. The gut microbiota exhibited a linear dose response to dietary perturbations, taking an average of 3.5 days for each diet-responsive bacterial group to reach a new steady state. Repeated dietary shifts demonstrated that most changes to the gut microbiota are reversible, while also uncovering bacteria whose abundance depends on prior consumption. These results emphasize the dominant role that diet plays in shaping interindividual variations in host-associated microbial communities.

Indexed as

DietFeeding BehaviorMicrobiotaAnimalsGastrointestinal TractMice

Identifiers

PMID25532804
PMCPMC4297240

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.