ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2015
Relationship between prenatal antibiotic use and asthma in at-risk children.
Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05759351 (Appendectomy During Pregnancy in General Anesthesia With Perioperative Management Does Not Influence Normal Child Development), which is not on this map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Appendectomy During Pregnancy in General Anesthesia With Perioperative Management Does Not Influence Normal Child Development: 10-year Study
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Prenatal maternal antibiotic use increases the risk of childhood eczema: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review.BMC pediatrics · 2020Pooled it
- Trial
- From ideal respiratory health to chronic lung disease: indicators of impaired respiratory health.Expert review of respiratory medicine · 2026Review
- The hidden cost of antibiotics: microbial dysbiosis-induced SCFA imbalance and its underlying mechanisms.Frontiers in immunology · 2026Review
- Prevalence and factors associated with the irrational use of antibiotics by pregnant women in the city of Marrakech, Morocco: a cross-sectional study.BMC pregnancy and childbirth · 2025Article
- The role of residual (veterinary) antibiotics in chemical exposome analysis: Current progress and future perspectives.Comprehensive reviews in food science and food safety · 2025Review
- Shaping immunity: the influence of the maternal gut bacteria on fetal immune development.Seminars in immunopathology · 2025Review
- Antibiotic exposure during pregnancy increases risk for childhood atopic diseases: a nationwide cohort study.European journal of medical research · 2024Article
- Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae.International journal of molecular sciences · 2024Article
- Establishing obstetrics-specific metrics and interventions for antimicrobial stewardship.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2023Article
- First-Day-of-Life Rectal Swabs Fail To Represent Meconial Microbiota Composition and Underestimate the Presence of Antibiotic Resistance Genes.Microbiology spectrum · 2023Article
- Effects of prenatal antibiotic treatment on early infant health: a retrospective study in a rural health facility in Ghana.African health sciences · 2023Article
- Antibiotic Use During Pregnancy and Childbirth: Prospective Observational Study on Prevalence, Indications, and Prescribing Patterns in a German Tertiary Center.Geburtshilfe und Frauenheilkunde · 2023Article
- The impact of early-life antibiotics and probiotics on gut microbial ecology and infant health outcomes: a Pregnancy and Birth Cohort in Northwest China (PBCC) study protocol.BMC pediatrics · 2022Article
- Discrete role for maternal stress and gut microbes in shaping maternal and offspring immunity.Neurobiology of stress · 2022Article
- Maternal antibiotic use and infections during pregnancy and offspring asthma: the Norwegian Mother, Father and Child Cohort Study and a nationwide register cohort.European journal of epidemiology · 2022Article
- Perceptions and reported practices of pregnant women and mothers of children under two years of age regarding antibiotic use and resistance in Vientiane province, Lao PDR: a qualitative study.BMC pregnancy and childbirth · 2022Article
- Respiratory and Intestinal Microbiota in Pediatric Lung Diseases-Current Evidence of the Gut-Lung Axis.International journal of molecular sciences · 2022Review
- Asthma and the Missing Heritability Problem: Necessity for Multiomics Approaches in Determining Accurate Risk Profiles.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAsthma prevalence has doubled in developed countries during the past 30 years. Pre- and perinatal events are essential in shaping the development of the immune system and systemic antibiotic use during this time could alter the maternal or placental microbiome, leading to an increase in the child's risk of developing asthma.
objectiveTo determine whether prenatal antibiotic use is associated with asthma and wheezing in children at risk for asthma.
methodsUsing data from a randomized education intervention of families at risk for asthma from 1998 followed through 2009 in urban Chicago, asthma was defined as ever having a physician asthma diagnosis by year 3 and wheezing in the third year. Logistic regression models controlling for confounders investigated the effect of antibiotic use during pregnancy on these outcomes.
resultsAfter adjustment, prenatal antibiotic use was a risk factor for asthma (odds ratio 3.1, 95% confidence interval 1.4-6.8) but was only weakly associated with wheezing (odds ratio 1.8, 95% confidence interval 0.9-3.3). Analyses of the effects of timing of prenatal antibiotic use on asthma and wheezing showed the relation remained consistent for antibiotic use later in pregnancy, but the outcomes were not associated with antibiotic use in the first trimester.
conclusionThis study suggests prenatal antibiotic use might be associated with the development of asthma in children at risk for asthma. Although the relation with prenatal antibiotics does not hold for wheezing in this study, there might be a trend that could be delineated further within a larger cohort study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.