ArticleAsian journal of andrology
Serum 25-hydroxyvitamin D levels and testosterone deficiency in middle-aged Korean men: a cross-sectional study.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Relationship of Vitamin D status with testosterone levels: a systematic review and meta-analysis.Endocrine · 2021Pooled it
- Vitamin D Supplementation and Testosterone Levels in Breast Cancer Survivors.International journal of molecular sciences · 2025Trial
- Dietary patterns and testosterone balance: a review of clinical data and perspectives.Journal of advanced research · 2026Review
- Association between serum 25-hydroxyvitamin D level and sex steroid hormone among 6-19-year old children and adolescents based on NHANES 2013-2016 data.Hormones (Athens, Greece) · 2026Article
- The Association Between Vitamin D Levels and Erectile Dysfunction in Men: A Systematic Review.Journal of clinical medicine · 2025Review
- Association of 25-hydroxyvitamin D with sex hormones and body composition in Chinese older adults.Frontiers in endocrinology · 2025Article
- The Impact of Vitamin D on Androgens and Anabolic Steroids among Adult Males: A Meta-Analytic Review.Diseases (Basel, Switzerland) · 2024Review
- Impact of vitamin D supplementation as COVID-19 vaccine adjuvant on sperm parameters and sex hormones in men with idiopathic infertility: Two separate pre-post studies.Clinical and experimental reproductive medicine · 2024Article
- Article
- Effects of Vitamin D Supplementation on Testosterone, Prostate, and Lower Urinary Tract Symptoms: A Prospective, Comparative Study.The world journal of men's health · 2023Article
- Association Between 25-hydroxyvitamin D Levels and Testosterone in Healthy, Non-Obese, Young Adult, Filipino Men.Journal of the ASEAN Federation of Endocrine Societies · 2023Article
- The Association between Vitamin D and the Components of Male Fertility: A Systematic Review.Biomedicines · 2022Review
- Functional hypogonadism among patients with obesity, diabetes, and metabolic syndrome.International journal of impotence research · 2022Review
- Factors Defining the Association Between Vitamin D and Testosterone in Males With Type 2 Diabetes and Hypogonadism.Frontiers in endocrinology · 2022Article
- Is there a relationship between serum vitamin D and semen parameters? A cross-sectional sample of the Iranian infertile men.Basic and clinical andrology · 2021Article
- Correlative studies on vitamin D and total, free bioavailable testosterone levels in young, healthy men.Scientific reports · 2021Article
- Vitamin D and Male Erectile Function: An Updated Review.The world journal of men's health · 2021Review
- Vitamin D and Male Fertility: An Updated Review.The world journal of men's health · 2020Review
- Sex Differences of Vitamin D Status across BMI Classes: An Observational Prospective Cohort Study.Nutrients · 2019Observational
- Gender Differences in Vitamin D Status in China.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have demonstrated that male hypogonadism is associated with a low level of vitamin D. However, no reports have investigated the effects of vitamin D on testosterone levels in Korean men. Our aim was to investigate whether testosterone levels are associated with serum vitamin D levels and whether seasonal variation exists. This cross-sectional study analyzed serum 25-hydroxyvitamin D [25(OH)D], total testosterone (TT), and free testosterone (FT) in 652 Korean men over 40 years of age who had undergone a comprehensive medical examination. The average age of the subjects was 56.7 ± 7.9 years, and the mean serum 25(OH)D, TT and FT levels were 21.23 ± 7.9 ng ml-1 , 4.70 ± 1.6 ng ml-1 , and 8.12 ± 3.3 pg ml-1 , respectively. In the multiple linear regression model, 25(OH)D showed positive association with TT (β =0.137, P< 0.001) and FT (β =0.103, P= 0.008). 25(OH)D and FT showed similar seasonal or monthly variation after adjustment for age. A vitamin D deficiency [25(OH)D < 20 ng ml-1 ] was associated with an increased risk of deficiencies of TT (<2.30 ng ml-1 ) (odds ratio [OR]: 2.65; 95% confidence interval [CI]: 1.21-5.78, P= 0.014) and FT (<6.50 pg ml-1 ) (OR: 1.44; 95% CI: 1.01-2.06 P= 0.048) after adjusting for age, season, body mass index, body composition, chronic disease, smoking, and alcohol use. In conclusion, we demonstrated a positive correlation between 25(OH)D and testosterone, which showed similar seasonal variation in Korean men.
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