Evidence map›Paper›PMID 25532536›Full record

Trial reportBMC immunology2014

Early changes of the kinetics of monocyte trem-1 reflect final outcome in human sepsis.

Androniki Marioli, Marina Koupetori, Maria Raftogiannis, Maria Patrani, Nikolaos Antonakos, Maria Pavlaki, Georgios Adamis, Georgia Dougekou, Georgia Damoraki, Iraklis Tsangaris

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Androniki Marioli2nd Department of Internal Medicine, Sismanogleion General Hospital, 15126, Athens, Greece. nmarioli@yahoo.gr.
Marina Koupetori1st Department of Internal Medicine, Thriasio General Hospital, 19600, Elefsis, Greece. e-Lambros@hotmail.gr.
Maria Raftogiannis4th Department of Internal Medicine, Medical School, University of Athens, 12462, Athens, Greece. mrafotgiann@med.uoa.gr.
Maria PatraniIntensive Care Unit, Korgialeneion-Benakeion Hospital, 11526, Athens, Greece. mpatrani@gmail.com.
Nikolaos Antonakos4th Department of Internal Medicine, Medical School, University of Athens, 12462, Athens, Greece. doc.kantonak@gmail.com.
Maria PavlakiDepartment of Internal Medicine, Argos General Hospital, 21200, Argos, Greece. mar_paul300@yahoo.gr.
Georgios Adamis1st Department of Internal Medicine, G.Gennimatas General Hospital, 11527, Athens, Greece. geo.adamis@gmail.com.
Georgia Dougekou4th Department of Internal Medicine, Medical School, University of Athens, 12462, Athens, Greece. diamanti.kons@gmail.com.
Georgia Damoraki4th Department of Internal Medicine, Medical School, University of Athens, 12462, Athens, Greece. gdamoraki@gmail.com.
Iraklis Tsangaris2nd Critical Care Department, "Attikon" University Hospital, 1 Rimini Str., Athens, 12462, Greece. itsagkaris@med.uoa.gr.
National and Kapodistrian University of Athens · GRArgo (Greece) · GRGeneral Hospital of Athens G. Genimatas · GRSismanoglio General Hospital · GRThriasio General Hospital of Elefsina · GRUniversity General Hospital Attikon · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTREM-1 (triggering receptor expressed on myeloid cells), a receptor expressed on neutrophils and monocytes, is upregulated in sepsis and seems to tune the inflammatory response. We explored the expression of TREM-1 at the gene level and on cell membranes of monocytes and association with clinical outcome.

methodsPeripheral venous blood was sampled from 75 septic patients (39 patients with sepsis, 25 with severe sepsis and 11 with septic shock) on sepsis days 1, 3 and 7. TREM-1 on monocytes was measured by flow cytometry; gene expression of TREM-1 in circulating mononuclear cells was assessed by real-time PCR. sTREM-1 was measured in serum by an enzyme immunoassay.

resultsAlthough surface TREM-1, sTREM-1 and TREM-1 gene expression did not differ between sepsis, severe sepsis and septic shock on day 1, survivors had greater expression of surface TREM-1 on days 3 and 7 compared to non-survivors. sTREM-1 on non-survivors decreased on day 3 compared to baseline. Patients with increase of monocyte gene expression of TREM-1 from day 1 to day 3 had prolonged survival compared to patients with decrease of gene expression of TREM-1 from day 1 to day 3 (p: 0.031).

conclusionsEarly decrease of gene expression of TREM-1 in monocytes is associated with poor outcome. A reciprocal decrease of the pro-inflammatory surface receptor TREM-1 linked with sepsis-induced immunosuppression may be part of the explanation.

Indexed as

Membrane GlycoproteinsMonocytesReceptors, ImmunologicSepsisAgedAged, 80 and overDisease-Free SurvivalFemaleFollow-Up StudiesGene Expression RegulationHumansKineticsMaleMiddle AgedSurvival RateTriggering Receptor Expressed on Myeloid Cells-1Membrane GlycoproteinsReceptors, ImmunologicTREM1 protein, humanTriggering Receptor Expressed on Myeloid Cells-1

Identifiers

PMID25532536
PMCPMC4335537
OpenAlexW2093143918

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.