Evidence map›Paper›PMID 25532443›Full record

ArticleAddictive behaviors2015

Neural activation during response inhibition is associated with adolescents' frequency of risky sex and substance use.

Sarah W Feldstein Ewing, Jon M Houck, Angela D Bryan

Abstract read
In one paragraph

Article in Addictive behaviors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Bidirectional links between adolescent brain function and substance use moderated by cognitive control.Journal of child psychology and psychiatry, and allied disciplines · 2021
    Article
  4. Article
  5. Article
  6. Sexual risk-taking and subcortical brain volume in adolescence.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018
    Article
  7. Neural activation during delay discounting is associated with 6-month change in risky sexual behavior in adolescents.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018
    Article
  8. Neural Correlates of Risky Sex and Response Inhibition in High-Risk Adolescents.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2018
    Article
  9. Working memory capacity and addiction treatment outcomes in adolescents.The American journal of drug and alcohol abuse · 2018
    Article
  10. Article
  11. Neural Interaction Between Risk Sensitivity and Cognitive Control Predicting Health Risk Behaviors Among Late Adolescents.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2017
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. The Neuropsychology of Risky Sexual Behavior.Journal of the International Neuropsychological Society : JINS · 2016
    Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sarah W Feldstein EwingUniversity of New Mexico, Department of Psychiatry, 1 University of New Mexico, MSC09 5030, Albuquerque, NM 87131, USA. Electronic address: swfeld@unm.edu.
Jon M HouckUniversity of New Mexico, Center on Alcoholism, Substance Abuse, and Addictions (CASAA), 2650 Yale Blvd SE, MSC11 6280, Albuquerque, NM 87106, USA.
Angela D BryanThe University of Colorado at Boulder, Department of Psychology and Neuroscience, Muenzinger D244, 345 UCB, Boulder, CO 80309-0345, USA.

Funding

HIV prevention with adolescents: Neurocognitive deficits and treatment responseR01AA017390 · NIAAA · UNIVERSITY OF NEW MEXICO · PI BRYAN, ANGELA · 2007 to 2011
$3.1M
Imaging Brain Activity in Substance Use TreatmentK01AA021431 · NIAAA · UNIVERSITY OF NEW MEXICO · PI HOUCK, JON M. · 2013 to 2017
$837k
The Effects of Client Change Talk on Risky Sexual BehaviorR03DA035690 · NIDA · UNIVERSITY OF NEW MEXICO · PI HOUCK, JON M. · 2013 to 2014
$312k
NIAAA NIH HHS 1R01 AA017390-01NIAAA NIH HHS K01 AA021431NIAAA NIH HHS K01AA021431NIAAA NIH HHS R01 AA017390NIDA NIH HHS L30 DA034353NIDA NIH HHS R03 DA035690
6 · The paper itself

Abstract

objective

introductionWhile many have identified the important role of the developing brain in youth risk behavior, few have examined the relationship between salient cognitive factors (response inhibition) and different types of real-world adolescent health risk behaviors such as substance use and risky sex, within the same sample of youth.

methodsWe therefore sought to examine these relationships with 95 high-risk youth (ages 14-18; M age = 16.29 years). We examined blood oxygen level dependent (BOLD) response to an fMRI-based cognitive task designed to assess response inhibition (Go/NoGo) and past month risk behavior (number of substance use days; number of unprotected sex days).

resultsFor this sample of youth, we found significant negative correlations between past month substance use and response inhibition within the left inferior frontal gyrus (IFG) and right insula (uncorrected p < .001; extent threshold ≥ 10 voxels). In addition, in the same contrast, we found significant positive correlations between past month risky sex and activation within the right IFG and left middle occipital gyrus (uncorrected p < .001; extent threshold ≥ 10 voxels).

conclusionsThese results suggest the particular relevance of these regions in this compelling, albeit slightly different, pattern of response for adolescent risky behaviors.

Indexed as

Inhibition, PsychologicalRisk-TakingAdolescentAdolescent BehaviorBrainBrain MappingFemaleHumansMagnetic Resonance ImagingMaleRisk FactorsSexual BehaviorSubstance-Related DisordersAdolescentAlcoholCannabisCognitivefMRISexual intercourse

Identifiers

PMID25532443
PMCPMC4354873

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.