ArticleNature methods2015
Macromolecular X-ray structure determination using weak, single-wavelength anomalous data.
Article in Nature methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The Untangle Challenge for accurate ensemble models.bioRxiv : the preprint server for biology · 2026Article
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- Structural insights into plasmalemma vesicle-associated protein (PLVAP): Implications for vascular endothelial diaphragms and fenestrae.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Application of sulfur SAD to small crystals with a large asymmetric unit and anomalous substructure.Acta crystallographica. Section D, Structural biology · 2022Article
- Likelihood-based estimation of substructure content from single-wavelength anomalous diffraction (SAD) intensity data.Acta crystallographica. Section D, Structural biology · 2021Article
- Evaluating crystallographic likelihood functions using numerical quadratures.Acta crystallographica. Section D, Structural biology · 2020Article
- SAD phasing of XFEL data depends critically on the error model.Acta crystallographica. Section D, Structural biology · 2019Article
- Article
- An introduction to experimental phasing of macromolecules illustrated by SHELX; new autotracing features.Acta crystallographica. Section D, Structural biology · 2018Article
- Maximum-likelihood determination of anomalous substructures.Acta crystallographica. Section D, Structural biology · 2018Article
- The hidden treasure in your data: phasing with unexpected weak anomalous scatterers from routine data sets.Acta crystallographica. Section F, Structural biology communications · 2017Article
- Contemporary Use of Anomalous Diffraction in Biomolecular Structure Analysis.Methods in molecular biology (Clifton, N.J.) · 2017Review
- Selenium single-wavelength anomalous diffraction de novo phasing using an X-ray-free electron laser.Nature communications · 2016Article
- Merging of synchrotron serial crystallographic data by a genetic algorithm.Acta crystallographica. Section D, Structural biology · 2016Article
- Improving the efficiency of molecular replacement by utilizing a new iterative transform phasing algorithm.Acta crystallographica. Section A, Foundations and advances · 2016Article
- Article
- Can I solve my structure by SAD phasing? Planning an experiment, scaling data and evaluating the useful anomalous correlation and anomalous signal.Acta crystallographica. Section D, Structural biology · 2016Article
- Initiating heavy-atom-based phasing by multi-dimensional molecular replacement.Acta crystallographica. Section D, Structural biology · 2016Article
- Data-collection strategy for challenging native SAD phasing.Acta crystallographica. Section D, Structural biology · 2016Article
- Can I solve my structure by SAD phasing? Anomalous signal in SAD phasing.Acta crystallographica. Section D, Structural biology · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We describe a likelihood-based method for determining the substructure of anomalously scattering atoms in macromolecular crystals that allows successful structure determination by single-wavelength anomalous diffraction (SAD) X-ray analysis with weak anomalous signal. With the use of partial models and electron density maps in searches for anomalously scattering atoms, testing of alternative values of parameters and parallelized automated model-building, this method has the potential to extend the applicability of the SAD method in challenging cases.
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