ArticleThe Journal of clinical endocrinology and metabolism2015
Continuous glucose monitoring and its relationship to hemoglobin A1c and oral glucose tolerance testing in obese and prediabetic youth.
Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- ISPAD Clinical Practice Consensus Guidelines 2024: Type 2 Diabetes in Children and Adolescents.Hormone research in paediatrics · 2024Guideline
- Reversibility of brain glucose kinetics in type 2 diabetes mellitus.Diabetologia · 2022Trial
- Glycaemic Profiles of Children With Overweight and Obesity in Free-living Conditions in Association With Cardiometabolic Risk.Scientific reports · 2016Trial
- Prediabetes in children and adolescents: what do we need to know?Annals of pediatric endocrinology & metabolism · 2026Article
- Alternative approaches to glucose measurements during oral glucose tolerance testing in youth with cystic fibrosis: a mixed methods pilot study.Journal of clinical & translational endocrinology · 2025Article
- Article
- Continuous Glucose Monitoring Use in Youth with Type 2 Diabetes: A Pilot Randomized Study.Diabetes technology & therapeutics · 2025Article
- Feasibility, Acceptability, and Validity of Home Continuous Glucose Monitoring-Based Oral Glucose Tolerance Test in Youth.The Journal of clinical endocrinology and metabolism · 2025Observational
- Continuous Glucose Monitoring-New Diagnostic Tool in Complex Pathophysiological Disorder of Glucose Metabolism in Children and Adolescents with Obesity.Diagnostics (Basel, Switzerland) · 2024Review
- Preconception HbA1c Levels in Adolescents and Young Adults and Adverse Birth Outcomes.JAMA network open · 2024Article
- Real-Time Continuous Glucose Monitoring in Adolescents and Young Adults With Type 2 Diabetes Can Improve Quality of Life.Journal of diabetes science and technology · 2024Article
- Prediabetes in children and adolescents: A ticking bomb!World journal of clinical pediatrics · 2024Article
- Screening for Turner Syndrome-Associated Hyperglycemia: Evaluating Hemoglobin A1c and Fasting Blood Glucose.Hormone research in paediatrics · 2024Article
- Are glucose and insulin levels at all time points during OGTT a reliable marker of diabetes mellitus risk in pediatric obesity?Journal of endocrinological investigation · 2023Article
- Oral glucose tolerance test: Ηow to maximize its diagnostic value in children and adolescents.Acta bio-medica : Atenei Parmensis · 2022Article
- Continuous Glucose Monitoring in Healthy Adults-Possible Applications in Health Care, Wellness, and Sports.Sensors (Basel, Switzerland) · 2022Review
- Incidence of hyperglycaemic disorders in children and adolescents with obesity.Pediatric endocrinology, diabetes, and metabolism · 2022Article
- Individual Postprandial Glycemic Responses to Diet in n-of-1 Trials: Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR).The Journal of nutrition · 2021Article
- Diagnosis, treatment and prevention of type 2 diabetes mellitus in children and adolescents.World journal of diabetes · 2021Review
- Body Composition and Markers of Cardiometabolic Health in Transgender Youth on Gonadotropin-Releasing Hormone Agonists.Transgender health · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
contextThe optimal screening test for diabetes and prediabetes in obese youth is controversial.
objectiveWe examined whether glycosylated hemoglobin (HbA1c) or the oral glucose tolerance test (OGTT) is a better predictor of free-living glycemia as measured by continuous glucose monitoring (CGM).
designThis was a cross-sectional study of youth 10-18 years old, body mass index (BMI) 85th percentile or greater, with diabetes risk factors. SETTING AND
participantsParticipants (n = 118) with BMI 85th percentile or greater, not on medications for glucose management, were recruited from primary care and pediatric endocrinology clinics around Denver, Colorado.
interventionHbA1c, fasting plasma glucose, and 2-hour glucose were collected and all participants wore a blinded CGM for 72 hours.
main outcome measuresCGM outcomes were determined and descriptive statistics calculated. Performance characteristics at current American Diabetes Association cutpoints were compared with CGM outcomes.
resultsCGM data were successfully collected on 98 obese youth. Those with prediabetes had significantly higher average glucose, area under the curve (AUC), peak glucose, and time greater than 120 and greater than 140 mg/dL (P < .01) on CGM than youth with normal HbA1c or OGTT. HbA1c had a greater magnitude of correlation to CGM average glucose, AUC, and minimum glucose; 2-hour glucose had a greater magnitude of correlation to CGM SD, peak glucose, and time greater than 140 and greater than 200 mg/dL. However, there were no overall differences in the strength comparisons between 2-hour glucose and HbA1c correlations to CGM outcomes.
conclusionsIn obese youth, HbA1c and 2-hour glucose performed equally well at predicting free-living glycemia on CGM, suggesting that both are valid tests for dysglycemia screening.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.