ArticlePloS one2014
Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Pooled it
- Heart ventricle regeneration in the lizard Eublepharis macularius, the leopard gecko.NPJ Regenerative medicine · 2026Article
- Animal models to study cardiac regeneration.Nature reviews. Cardiology · 2024Review
- Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish.Cardiovascular research · 2022Article
- Loss of Caveolin-1 and caveolae leads to increased cardiac cell stiffness and functional decline of the adult zebrafish heart.Scientific reports · 2020Article
- Multiple cryoinjuries modulate the efficiency of zebrafish heart regeneration.Scientific reports · 2020Article
- Estrogen accelerates heart regeneration by promoting the inflammatory response in zebrafish.The Journal of endocrinology · 2020Article
- Adult sox10Cell reports · 2019Article
- Inhibition ofJournal of cardiovascular development and disease · 2019Article
- Adaptation of a Mice Doppler Echocardiography Platform to Measure Cardiac Flow Velocities for Embryonic Chicken and Adult Zebrafish.Frontiers in bioengineering and biotechnology · 2019Article
- Delineating the Dynamic Transcriptome Response of mRNA and microRNA during Zebrafish Heart Regeneration.Biomolecules · 2018Article
- Cardiac regeneration following cryoinjury in the adult zebrafish targets a maturation-specific biomechanical remodeling program.Scientific reports · 2018Article
- A Langendorff-like system to quantify cardiac pump function in adult zebrafish.Disease models & mechanisms · 2018Article
- Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish.Developmental cell · 2018Article
- Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration.Nature communications · 2018Article
- Physiological Responses to Swimming-Induced Exercise in the Adult Zebrafish Regenerating Heart.Frontiers in physiology · 2018Article
- High-Resolution Magnetic Resonance Imaging of the Regenerating Adult Zebrafish Heart.Scientific reports · 2017Article
- Zebrafish heart regeneration: 15 years of discoveries.Regeneration (Oxford, England) · 2017Review
- Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models.Disease models & mechanisms · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
aimsWhile zebrafish embryos are amenable to in vivo imaging, allowing the study of morphogenetic processes during development, intravital imaging of adults is hampered by their small size and loss of transparency. The use of adult zebrafish as a vertebrate model of cardiac disease and regeneration is increasing at high speed. It is therefore of great importance to establish appropriate and robust methods to measure cardiac function parameters. METHODS AND
resultsHere we describe the use of 2D-echocardiography to study the fractional volume shortening and segmental wall motion of the ventricle. Our data show that 2D-echocardiography can be used to evaluate cardiac injury and also to study recovery of cardiac function. Interestingly, our results show that while global systolic function recovered following cardiac cryoinjury, ventricular wall motion was only partially restored.
conclusionCryoinjury leads to long-lasting impairment of cardiac contraction, partially mimicking the consequences of myocardial infarction in humans. Functional assessment of heart regeneration by echocardiography allows a deeper understanding of the mechanisms of cardiac regeneration and has the advantage of being easily transferable to other cardiovascular zebrafish disease models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.