ReviewGerontology2015
Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review.
Review in Gerontology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Pooled it
- Evolution of Human Memory B Cells From Childhood to Old Age.Frontiers in immunology · 2021Trial
- Immune surveillance and microbial escape in the aging host: Why does the microbiome lose its balance?PLoS biology · 2026Review
- Bridging aging and colorectal cancer: synergistic roles of inflammaging and immunosenescence.Frontiers in immunology · 2026Review
- Epidemiological analysis of infectious diseases in older people in China from 2014 to 2022: a population-based study.The Lancet regional health. Western Pacific · 2025Article
- Dietary diversity and opportunistic infections among adults living with human immunodeficiency virus on antiretroviral therapy in Kumasi metropolis; a facility-based cross-sectional study.BMC infectious diseases · 2025Article
- Aging-related impairment of neurogenic chloride secretion in human colon mucosa.Frontiers in physiology · 2025Article
- The effect of T cell aging on the change of human tissue structure.Immunity & ageing : I & A · 2024Article
- The Impact of Immune System Aging on Infectious Diseases.Microorganisms · 2024Review
- The intestinal immune system and gut barrier function in obesity and ageing.The FEBS journal · 2023Review
- The role of retinoic acid in the production of immunoglobulin A.Mucosal immunology · 2022Review
- The role of T cells in age-related diseases.Nature reviews. Immunology · 2022Review
- Mucosal immunity to poliovirus.Mucosal immunology · 2022Review
- Gut mycobiome and its interaction with diet, gut bacteria and alzheimer's disease markers in subjects with mild cognitive impairment: A pilot study.EBioMedicine · 2020Article
- Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice.Scientific reports · 2019Article
- Food Allergies and Ageing.International journal of molecular sciences · 2019Review
- The Post-amyloid Era in Alzheimer's Disease: Trust Your Gut Feeling.Frontiers in aging neuroscience · 2019Review
- Resident Immunity in Tissue Repair and Maintenance: The Zebrafish Model Coming of Age.Frontiers in cell and developmental biology · 2019Article
- Age and Periodontal Health - Immunological View.Current oral health reports · 2018Article
- Ageing effects on humoral immune responses in chronic periodontitis.Journal of clinical periodontology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
It has been shown that pathogen-specific secretory IgA (SIgA) antibody (Ab) is the major player at mucosal surfaces for host defense. However, alterations in the mucosal immune system occur in advanced aging, which results in a failure of induction of SIgA Abs for the protection from infectious diseases. Signs of mucosal senescence first appear in the gut immune system. Further, changes in the intestinal microbiota most likely influence mucosal immunity. To overcome the immunological aging decline in mucosal immunity, several adjuvant systems including mucosal dendritic cell targeting have been shown to be attractive and effective immunological strategies. Similarly, microfold (M) cells involved in the antigen (Ag) uptake are ideal targets for facilitating Ag-specific mucosal immune responses. However, the numbers of M cells are reduced in aged mice. In this regard, Spi-B, an essential transcription factor for the functional and structural differentiation of M cells, could be a potent strategy for the induction of effective mucosal immunity in aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.