Evidence map›Paper›PMID 25531687›Full record

ReviewNeurodegenerative disease management2014

Frontotemporal dementia: diagnosis, deficits and management.

Nicholas T Bott, Anneliese Radke, Melanie L Stephens, Joel H Kramer

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurodegenerative disease management, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Premorbid de novo artistic creativity in frontotemporal dementia (FTD) syndromes.Journal of neural transmission (Vienna, Austria : 1996) · 2021
    Pooled it
  4. Pooled it
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  18. Blood-Based Biomarkers in Frontotemporal Dementia: A Narrative Review.International journal of molecular sciences · 2024
    Review
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicholas T BottDepartment of Neurology, Memory & Aging Center, University of California, 675 Nelson Rising Lane, Suite 190, San Francisco, CA 94158, USA.
Anneliese Radke
Melanie L Stephens
Joel H Kramer

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Decision-Making in Genetic FTDR01AG022983 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIONG, WINSTON · 2004 to 2021
$6.0M
NIA NIH HHS P01 AG019724NIA NIH HHS R01 AG022983
6 · The paper itself

Abstract

Frontotemporal dementia (FTD) is a progressive neurologic syndrome with diverse clinical presentations and attendant underlying pathologies. Psychiatric prodrome, neuropsychiatric symptoms and language difficulties are common in FTD, but the diversity of presentation raises unique diagnostic challenges that can significantly impact patient care and counsel for caregivers regarding clinical status and prognosis. While neuropsychiatric symptom measures are helpful, more sensitive assessments delineating the specific behavioral and linguistic deficits accompanying FTD are needed. Comprehensive clinical assessment in combination with evaluation of language, socio-emotional functioning, cognition and neuroimaging aid in accurate and early diagnosis and treatment planning. In what follows, we review each of the FTD syndromes, highlight current research investigating the cognitive, behavioral and socio-emotional deficits observed with this disease, address common diagnostic challenges and summarize best practices associated with management of FTD.

Indexed as

Alzheimer DiseaseFrontotemporal DementiaHumansMagnetic Resonance ImagingPrimary Progressive Nonfluent Aphasiadifferential diagnosisfrontotemporal dementianeuropsychologyprimary progressive aphasiasocio-emotional functioning

Identifiers

PMID25531687
PMCPMC4824317

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.