ArticleDementia and geriatric cognitive disorders2015
Interactions between traumatic brain injury and frontotemporal degeneration.
Article in Dementia and geriatric cognitive disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Article
- Traumatic brain injury and neurological stealth syndromes.Frontiers in neuroscience · 2026Article
- Senolytic Treatment Attenuates Global Ischemic Brain Injury and Enhances Cognitive Recovery by Targeting Mitochondria.Cellular and molecular neurobiology · 2025Article
- Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy.Molecular neurodegeneration · 2025Article
- Clinical implications of head trauma in frontotemporal dementia and primary progressive aphasia.Alzheimer's research & therapy · 2024Article
- Unusual combinations of neurodegenerative pathologies with chronic traumatic encephalopathy (CTE) complicates clinical prediction of CTE.European journal of neurology · 2024Article
- Computer-Based Naming Treatment for Semantic Variant Primary Progressive Aphasia With History of Traumatic Brain Injury: A Single-Case Experimental Design.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury.Acta neuropathologica communications · 2023Article
- Inflammaging, cellular senescence, and cognitive aging after traumatic brain injury.Neurobiology of disease · 2023Review
- Increased Risk of Aging-Related Neurodegenerative Disease after Traumatic Brain Injury.Biomedicines · 2023Review
- Rationale and design of the "NEurodegeneration: Traumatic brain injury as Origin of the Neuropathology (NEwTON)" study: a prospective cohort study of individuals at risk for chronic traumatic encephalopathy.Alzheimer's research & therapy · 2022Observational
- Modifiable potential risk factors in familial and sporadic frontotemporal dementia.Annals of clinical and translational neurology · 2022Article
- Advanced brain age in deployment-related traumatic brain injury: A LIMBIC-CENC neuroimaging study.Brain injury · 2022Article
- Traumatic Brain Injury and Early Onset Dementia in Post 9-11 Veterans.Brain injury · 2022Article
- Traumatic Brain Injury and Risk of Neurodegenerative Disorder.Biological psychiatry · 2022Review
- Alzheimer's Disease-Related Dementias Summit 2019: National Research Priorities for the Investigation of Traumatic Brain Injury as a Risk Factor for Alzheimer's Disease and Related Dementias.Journal of neurotrauma · 2021Article
- Zebrafish Blunt-Force TBI Induces Heterogenous Injury Pathologies That Mimic Human TBI and Responds with Sonic Hedgehog-Dependent Cell Proliferation across the Neuroaxis.Biomedicines · 2021Article
- The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample.Frontiers in neurology · 2021Article
- Traumatic Brain Injury Exposure Lowers Age of Cognitive Decline in AD and Non-AD Conditions.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsPrior work in smaller cohorts suggests that traumatic brain injury (TBI) may be a risk factor for frontotemporal degeneration (FTD). We sought to confirm and extend these results using the National Alzheimer's Coordinating Center Uniform Data Set.
methodsWe compared the TBI prevalence between FTD subjects and matched normal controls. Indices of cognitive, behavioral, functional, and global dementia severity were compared between FTD subjects with and without prior TBI.
resultsRemote TBI with extended loss of consciousness (TBI-ext) was more common in individuals with FTD than in controls (OR: 1.67; 95% CI: 1.004-2.778). With TBI-ext, less functional and global impairment was seen in the behavioral variant of FTD, but more behavioral pathology was seen in the semantic variant.
conclusionTBI may increase the FTD risk and influence clinical symptomatology and severity in FTD subtypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.