ArticlePloS one2014
A minimal dose of electrically induced muscle activity regulates distinct gene signaling pathways in humans with spinal cord injury.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Novel Intervention to Influence Muscle Plasticity in Veterans
Musculoskeletal Plasticity After Spinal Cord Injury
Long Duration Activity and Metabolic Control After Spinal Cord Injury
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Precision Rehabilitation in Spinal Cord Injury: A Systematic Review of Omics Applications for Intervention Monitoring in Spinal Cord Injury.Archives of rehabilitation research and clinical translation · 2026Review
- Development of a Flexible Electrode for Electrical Stimulation of Rabbit Extraocular Muscle.Korean journal of ophthalmology : KJO · 2025Article
- Article
- Distinct Genomic Expression Signatures after Low-Force Electrically Induced Exercises in Persons with Spinal Cord Injury.International journal of molecular sciences · 2024Article
- Impaired Glucose Tolerance and Visceral Adipose Tissue Thickness among Lean and Non-Lean People with and without Spinal Cord Injury.Journal of functional morphology and kinesiology · 2023Article
- Acute Low Force Electrically Induced Exercise Modulates Post Prandial Glycemic Markers in People with Spinal Cord Injury.Journal of functional morphology and kinesiology · 2022Article
- Alterations in Protein Translation and Carboxylic Acid Catabolic Processes in Diabetic Kidney Disease.Cells · 2022Article
- Genomic and Epigenomic Evaluation of Electrically Induced Exercise in People With Spinal Cord Injury: Application to Precision Rehabilitation.Physical therapy · 2022Article
- Mechanisms of exercise as a preventative measure to muscle wasting.American journal of physiology. Cell physiology · 2021Review
- Impact of short- and long-term electrically induced muscle exercise on gene signaling pathways, gene expression, and PGC1a methylation in men with spinal cord injury.Physiological genomics · 2020Article
- Hybrid stimulation enhances torque as a function of muscle fusion in human paralyzed and non-paralyzed skeletal muscle.The journal of spinal cord medicine · 2019Article
- Mitochondrial health and muscle plasticity after spinal cord injury.European journal of applied physiology · 2019Review
- Region of Interest analysis using mass spectrometry imaging of mitochondrial and sarcomeric proteins in acute cardiac infarction tissue.Scientific reports · 2018Article
- What Can be Learned from the Time Course of Changes in Low-Frequency Stimulated Muscle?European journal of translational myology · 2017Article
- Endurance neuromuscular electrical stimulation training improves skeletal muscle oxidative capacity in individuals with motor-complete spinal cord injury.Muscle & nerve · 2017 · on this mapArticle
- Low-Force Muscle Activity Regulates Energy Expenditure after Spinal Cord Injury.Medicine and science in sports and exercise · 2017Article
- Review
- The nuclear receptor NOR-1 regulates the small muscle protein, X-linked (SMPX) and myotube differentiation.Scientific reports · 2016Article
- Distinct Skeletal Muscle Gene Regulation from Active Contraction, Passive Vibration, and Whole Body Heat Stress in Humans.PloS one · 2016Article
- MicroRNA-208b progressively declines after spinal cord injury in humans and is inversely related to myostatin expression.Physiological reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Paralysis after a spinal cord injury (SCI) induces physiological adaptations that compromise the musculoskeletal and metabolic systems. Unlike non-SCI individuals, people with spinal cord injury experience minimal muscle activity which compromises optimal glucose utilization and metabolic control. Acute or chronic muscle activity, induced through electrical stimulation, may regulate key genes that enhance oxidative metabolism in paralyzed muscle. We investigated the short and long term effects of electrically induced exercise on mRNA expression of human paralyzed muscle. We developed an exercise dose that activated the muscle for only 0.6% of the day. The short term effects were assessed 3 hours after a single dose of exercise, while the long term effects were assessed after training 5 days per week for at least one year (adherence 81%). We found a single dose of exercise regulated 117 biological pathways as compared to 35 pathways after one year of training. A single dose of electrical stimulation increased the mRNA expression of transcriptional, translational, and enzyme regulators of metabolism important to shift muscle toward an oxidative phenotype (PGC-1α, NR4A3, IFRD1, ABRA, PDK4). However, chronic training increased the mRNA expression of specific metabolic pathway genes (BRP44, BRP44L, SDHB, ACADVL), mitochondrial fission and fusion genes (MFF, MFN1, MFN2), and slow muscle fiber genes (MYH6, MYH7, MYL3, MYL2). These findings support that a dose of electrical stimulation (∼10 minutes/day) regulates metabolic gene signaling pathways in human paralyzed muscle. Regulating these pathways early after SCI may contribute to reducing diabetes in people with longstanding paralysis from SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.