ArticleThe Angle orthodontist2015
Epidemiology and genetics of hypodontia and microdontia: a study of twin families.
Article in The Angle orthodontist, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 26 citations in OpenAlex.
- Influences of genetic and environmental factors on developmental dental anomalies: a twin study.BMC oral health · 2025Article
- Comprehensive Oral Diagnosis and Management for Women with Turner Syndrome.Diagnostics (Basel, Switzerland) · 2024Article
- "Examining the link between tooth agenesis and papillary thyroid cancer: is there a risk factor?" Observational study.Progress in orthodontics · 2024Observational
- Dental caries and dental developmental defects as adverse effects of antineoplastic treatment in childhood cancer survivors.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Article
- Aesthetic and Functional Rehabilitation of Patients with Genetic Microdontia: A Multidisciplinary Approach.Healthcare (Basel, Switzerland) · 2022Article
- Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism.BMC oral health · 2019Article
- Prevalence and Characteristics of Developmental Dental Anomalies in Iranian Orofacial Cleft Patients.Journal of dentistry (Shiraz, Iran) · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify genetic and environmental factors contributing to hypodontia and microdontia by using Korean twin family data. MATERIALS AND
methodsA total of 1267 individuals (525 men and 742 women; 180 monozygotic twins [MZ] and 43 dizygotic twins [DZ] from 282 families) underwent an oral examination as part of the Healthy Twin Study in Korea. Dental anomalies classified as hypodontia or microdontia were diagnosed using radiographs and clinical examinations. In order to estimate genetic contributions to dental anomalies, we estimated the pairwise concordance rate (PCR), recurrence risk ratio (RRR), and heritability (h2).
resultsThe prevalence of hypodontia and microdontia was 3.55% and 3.00%, respectively. MZ had the highest PCR and RRR (13.0-15.3). The PCR and RRR values for both anomalies were much higher for DZ (5.0-11.9) than for siblings (1.4-2.6), despite the fact that DZ pairs and sibling pairs share 50% genetic identity. Further genetic analysis revealed both an additive genetic effect (0.38 when hypodontia and microdontia were pooled) and a strong "twin effect" (0.52 when hypodontia and microdontia were pooled).
conclusionsThis twin-based study revealed that the formation of dental anomalies is affected by both genetic and environmental factors, and that the impact of these factors varies according to the specific dental anomaly.
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