ArticleViral immunology2015
Multiple circulating infections can mimic the early stages of viral hemorrhagic fevers and possible human exposure to filoviruses in Sierra Leone prior to the 2014 outbreak.
Article in Viral immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Identifying genomic surveillance gaps in Africa for the global public health response to West Nile virus: a systematic review.The Lancet. Microbe · 2025Pooled it
- Epidemiology of West Nile virus in Africa: An underestimated threat.PLoS neglected tropical diseases · 2022Pooled it
- A systematic review and meta-analysis of seroprevalence surveys of ebolavirus infection.Scientific data · 2017Pooled it
- Lassa fever in Bauchi State, Nigeria: communication channels and health-seeking behavior.IJID regions · 2025Article
- Baseline Seroprevalence of Arboviruses in Liberia Using a Multiplex IgG Immunoassay.Tropical medicine and infectious disease · 2025Article
- Review
- The Threat of Vector-Borne Diseases in Sierra Leone.The American journal of tropical medicine and hygiene · 2023Review
- Lassa Fever Natural History and Clinical Management.Current topics in microbiology and immunology · 2023Article
- Health seeking behavior after the 2013-16 Ebola epidemic: Lassa fever as a metric of persistent changes in Kenema District, Sierra Leone.PLoS neglected tropical diseases · 2021Article
- Field evaluation of a Pan-Lassa rapid diagnostic test during the 2018 Nigerian Lassa fever outbreak.Scientific reports · 2020Article
- Immune correlates of postexposure vaccine protection against Marburg virus.Scientific reports · 2020Article
- Lassa fever diagnostics: past, present, and future.Current opinion in virology · 2019Review
- Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever.Scientific reports · 2018Article
- Surveillance of Vector-Borne Infections (Chikungunya, Dengue, and Malaria) in Bo, Sierra Leone, 2012-2013.The American journal of tropical medicine and hygiene · 2017Article
- Metabolomics analyses identify platelet activating factors and heme breakdown products as Lassa fever biomarkers.PLoS neglected tropical diseases · 2017Article
- Analytical Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection.The Journal of infectious diseases · 2016Article
- An Outbreak of Ebola Virus Disease in the Lassa Fever Zone.The Journal of infectious diseases · 2016Article
- Serosurveillance of viral pathogens circulating in West Africa.Virology journal · 2016Article
- Diagnostics in Ebola Virus Disease in Resource-Rich and Resource-Limited Settings.PLoS neglected tropical diseases · 2016Review
- Epidemiology and Management of the 2013-16 West African Ebola Outbreak.Annual review of virology · 2016Review
Corrections and comments
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Authors and funding
34 authors at 8 institutions in 1 country.
Funding
Abstract
Lassa fever (LF) is a severe viral hemorrhagic fever caused by Lassa virus (LASV). The LF program at the Kenema Government Hospital (KGH) in Eastern Sierra Leone currently provides diagnostic services and clinical care for more than 500 suspected LF cases per year. Nearly two-thirds of suspected LF patients presenting to the LF Ward test negative for either LASV antigen or anti-LASV immunoglobulin M (IgM), and therefore are considered to have a non-Lassa febrile illness (NLFI). The NLFI patients in this study were generally severely ill, which accounts for their high case fatality rate of 36%. The current studies were aimed at determining possible causes of severe febrile illnesses in non-LF cases presenting to the KGH, including possible involvement of filoviruses. A seroprevalence survey employing commercial enzyme-linked immunosorbent assay tests revealed significant IgM and IgG reactivity against dengue virus, chikungunya virus, West Nile virus (WNV), Leptospira, and typhus. A polymerase chain reaction-based survey using sera from subjects with acute LF, evidence of prior LASV exposure, or NLFI revealed widespread infection with Plasmodium falciparum malaria in febrile patients. WNV RNA was detected in a subset of patients, and a 419 nt amplicon specific to filoviral L segment RNA was detected at low levels in a single patient. However, 22% of the patients presenting at the KGH between 2011 and 2014 who were included in this survey registered anti-Ebola virus (EBOV) IgG or IgM, suggesting prior exposure to this agent. The 2014 Ebola virus disease (EVD) outbreak is already the deadliest and most widely dispersed outbreak of its kind on record. Serological evidence reported here for possible human exposure to filoviruses in Sierra Leone prior to the current EVD outbreak supports genetic analysis that EBOV may have been present in West Africa for some time prior to the 2014 outbreak.
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