ArticleCaries research2015
Early childhood caries is associated with genetic variants in enamel formation and immune response genes.
Article in Caries research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis.Genes · 2026Pooled it
- Genes in the pathway of tooth mineral tissues and dental caries risk: a systematic review and meta-analysis.Clinical oral investigations · 2020Pooled it
- Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis.BMC oral health · 2020Pooled it
- Integrative Analysis ofDentistry journal · 2026Article
- Addressing Research Gaps in Early Childhood Caries: A Comprehensive Review.Dentistry journal · 2026Review
- Polymorphisms in SOD2 and SOD3 Genes are Associated with Dental Caries in Primary Dentition of Brazilian Children.Biochemical genetics · 2026Article
- Associations between the use of caries preventive methods and ECC experience in Ile-Ife, Nigeria: a cross-sectional study.BMC oral health · 2025Article
- Tooth Decay: Genetic and Epigenetic Insights Driving the Development of Anti-Caries Vaccines.Genes · 2025Review
- Association Between Genetic Variants inInternational journal of dentistry · 2025Article
- Managing Early Childhood Caries: A Comparative Review of Preventive and Restorative Approaches.Cureus · 2024Review
- Can the sustainable development goal 9 support an untreated early childhood caries elimination agenda?BMC oral health · 2024Review
- Polymorphisms inThe Saudi dental journal · 2024Article
- AMELX gene association to early childhood caries in south-Indian children: a case-control study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- Association between polymorphisms of immune response genes and early childhood caries - systematic review, gene-based, gene cluster, and meta-analysis.Journal, genetic engineering & biotechnology · 2023Review
- Polymorphisms in genes expressed during amelogenesis and their association with dental caries: a case-control study.Clinical oral investigations · 2023Article
- Evaluation of Beta-Defensin 1 and Mannose-Binding Lectin 2 Polymorphisms in Children with Dental Caries Compared to Caries-Free Controls: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Associations of PART1 and DEFB1 polymorphisms with Dental Caries in twelve-year-old children in Southern China: a cross-sectional study.BMC pediatrics · 2023Article
- Association of KLK4 rs2235091 polymorphism with susceptibility to dental caries: a systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
- AMELX and ENAM Polymorphisms and Dental Caries.International journal of dentistry · 2022Article
- The association between genetic polymorphisms in matrix metalloproteinases and caries experience.Clinical oral investigations · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of an imbalance of risk factors and protective factors that influence the disease. The aim of this study was to assess genetic and environmental factors that may contribute to ECC. Two hundred and fifty-nine unrelated children were evaluated using a cross-sectional design. Data on oral habits were obtained through a questionnaire, and caries experience data were collected by clinical examination. Twenty-three markers in 10 genes were studied. Genotyping of the selected polymorphisms was carried out by real-time PCR. Regression analyses were performed comparing individuals with and without caries experience. Of 259 subjects, 123 were caries free. The genotype TT in ALOX15 (rs7217186) was a risk factor for ECC, whereas the genotypes GG in ENAM (rs1264848), AG and GG in KLK4 (rs198968), CT in LTF (rs4547741), and GG in TUFT1 (rs3790506) were protective for EEC. In conclusion, environmental factors and gene interactions can act as protective or risk factors for ECC. These factors together contribute to the presence and severity of the disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.