Evidence map›Paper›PMID 25530982›Full record

ArticleACS photonics2014

Transmissive Nanohole Arrays for Massively-Parallel Optical Biosensing.

Yanan Wang, Archana Kar, Andrew Paterson, Katerina Kourentzi, Han Le, Paul Ruchhoeft, Richard Willson, Jiming Bao

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS photonics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Plasmonic biosensors.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yanan WangDepartment of Electrical and Computer Engineering and Department of Chemical and Biomolecular Engineering, University of Houston , Houston, Texas 77204, United States.
Archana KarDepartment of Electrical and Computer Engineering and Department of Chemical and Biomolecular Engineering, University of Houston , Houston, Texas 77204, United States.
Andrew PatersonDepartment of Electrical and Computer Engineering and Department of Chemical and Biomolecular Engineering, University of Houston , Houston, Texas 77204, United States.
Katerina KourentziDepartment of Electrical and Computer Engineering and Department of Chemical and Biomolecular Engineering, University of Houston , Houston, Texas 77204, United States.
Han LeDepartment of Electrical and Computer Engineering and Department of Chemical and Biomolecular Engineering, University of Houston , Houston, Texas 77204, United States.
Paul RuchhoeftDepartment of Electrical and Computer Engineering and Department of Chemical and Biomolecular Engineering, University of Houston , Houston, Texas 77204, United States.
Richard WillsonDepartment of Electrical and Computer Engineering and Department of Chemical and Biomolecular Engineering, University of Houston , Houston, Texas 77204, United States ; Centro de Biotecnología FEMSA, Departamento de Biotecnología e Ingeniería de Alimentos, Tecnológico de Monterrey , Monterrey, NL 64849, Mexico.
Jiming BaoDepartment of Electrical and Computer Engineering and Department of Chemical and Biomolecular Engineering, University of Houston , Houston, Texas 77204, United States.
Tecnológico de Monterrey · MX

Funding

WRCE Nonhuman Primate CoreU54AI057156 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI WALKER, DAVID H · 2003 to 2013
$102.6M
NIAID NIH HHS U54 AI057156
6 · The paper itself

Abstract

A high-throughput optical biosensing technique is proposed and demonstrated. This hybrid technique combines optical transmission of nanoholes with colorimetric silver staining. The size and spacing of the nanoholes are chosen so that individual nanoholes can be independently resolved in massive parallel using an ordinary transmission optical microscope, and, in place of determining a spectral shift, the brightness of each nanohole is recorded to greatly simplify the readout. Each nanohole then acts as an independent sensor, and the blocking of nanohole optical transmission by enzymatic silver staining defines the specific detection of a biological agent. Nearly 10000 nanoholes can be simultaneously monitored under the field of view of a typical microscope. As an initial proof of concept, biotinylated lysozyme (biotin-HEL) was used as a model analyte, giving a detection limit as low as 0.1 ng/mL.

Indexed as

biosensingcolorimetric detectionenzymatic silver stainingimmunoassaynanohole arraytransmission optical microscope

Identifiers

PMID25530982
PMCPMC4266487
OpenAlexW2319657239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.