Evidence map›Paper›PMID 25530905›Full record

ArticleStroke research and treatment2014

Impact of serum nutritional status on physical function in african american and caucasian stroke survivors.

Monica C Serra, Charlene E Hafer-Macko, Frederick M Ivey, Richard F Macko, Alice S Ryan

Open access · goldAbstract read
In one paragraph

Article in Stroke research and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Monica C SerraDepartment of Medicine, University of Maryland School of Medicine, 10 N Greene Street (BT/18/GR), Baltimore, MD 21201, USA ; Geriatric Research Education and Clinical Center, Baltimore Department of Veterans Affairs Medical Center (VAMC), Baltimore, MD 21201, USA.
Charlene E Hafer-MackoDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA ; Rehabilitation Research and Development's Maryland Exercise and Robotics Center of Excellence, Baltimore VAMC, Baltimore, MD 21201, USA.
Frederick M IveyDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA ; Rehabilitation Research and Development's Maryland Exercise and Robotics Center of Excellence, Baltimore VAMC, Baltimore, MD 21201, USA.
Richard F MackoDepartment of Medicine, University of Maryland School of Medicine, 10 N Greene Street (BT/18/GR), Baltimore, MD 21201, USA ; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA ; Rehabilitation Research and Development's Maryland Exercise and Robotics Center of Excellence, Baltimore VAMC, Baltimore, MD 21201, USA.
Alice S RyanDepartment of Medicine, University of Maryland School of Medicine, 10 N Greene Street (BT/18/GR), Baltimore, MD 21201, USA ; Geriatric Research Education and Clinical Center, Baltimore Department of Veterans Affairs Medical Center (VAMC), Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USGeriatric Research Education and Clinical Center · US

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Aging, Inflammation and Exercise in Chronic StrokeR01AG030075 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI HAFER-MACKO, CHARLENE E, RYAN, ALICE S. · 2008 to 2012
$2.4M
NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG030075NIDDK NIH HHS P30 DK072488
6 · The paper itself

Abstract

Background. The purpose of this study is to compare serum nutritional profiles in chronic stroke survivors to a representative sample of US Adults (NHANESIII) and determine whether these serum markers differed by race and impact physical function in stroke. Methods. Fasting serum samples were collected for analysis of lipids, uric acid, and albumin in 145 African American (AA) and 111 Caucasian (C) stroke survivors (age: 60 ± 1 years [mean ± SEM]). A six-minute walk was performed in a subset of stroke survivors (N = 134). Results. Triglycerides were higher and HDL-cholesterol and albumin lower in C than AA women stroke survivors (Ps < 0.05). Uric acid was lower in C than AA stroke survivors (P < 0.05). Compared to NHANESIII, HDL-cholesterol, albumin, and hemoglobin generally were lower (Ps < 0.05) and lipids were more favorable in stroke (Ps < 0.01). Uric acid was related to six-minute walk performance among a subset of stroke survivors (P < 0.05). Conclusion. In stroke, racial differences exist with regard to serum nutritional risk, but these differences are similar to that observed in the general population. Regardless of race, nutritional risk appears elevated above that of the general population with regard to many of the serum markers. As a modifiable biomarker, uric acid should be monitored closely as it may provide insight into the functional risk of stroke survivors.

Identifiers

PMID25530905
PMCPMC4229960
OpenAlexW2122082216

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.