Evidence map›Paper›PMID 25530854›Full record

ArticleJournal of materials chemistry. B2014

Improved cell infiltration of highly porous nanofibrous scaffolds formed by combined fiber-fiber charge repulsions and ultra-sonication.

Sung Isn Jeong, Nancy A Burns, Christopher A Bonino, Il Keun Kwon, Saad A Khan, Eben Alsberg

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Sung Isn JeongDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.
Nancy A BurnsDepartment of Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina.
Christopher A BoninoDepartment of Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina.
Il Keun KwonDepartment of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea.
Saad A KhanDepartment of Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina.
Eben AlsbergDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio ; Department of Orthopaedic Surgery, Case Western Reserve University, Cleveland, Ohio.
North Carolina State University · USCase Western Reserve University · USNational Medical Research Center of Dentistry and Maxillofacial Surgery · RU

Funding

Driving Tissue Formation by Inductive Stem Cell Sheet TechnologyR01AR063194 · NIAMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALSBERG, EBEN · 2012 to 2016
$1.7M
Growth Plate RegenerationR21AR061265 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI ALSBERG, EBEN, BALLOCK, ROBERT TRACY · 2012 to 2013
$392k
NIAMS NIH HHS R01 AR063194NIAMS NIH HHS R21 AR061265
6 · The paper itself

Abstract

A significant problem affecting electrospun nanofibrous tissue scaffolds is poor infiltration of cells into their three-dimensional (3D) structure. Environmental and physical manipulation, however, can enhance cellular infiltration into electrospun scaffolds. In this work, RGD-modified alginate mats with increased thickness and porosity were achieved by pairing high humidity electrospinning with post-processing ultra-sonication. RGD-modified alginate, polyethylene oxide (PEO), and an FDA-approved, nonionic surfactant blends were electrospun in 20 and 50% relative humidity conditions. Mats electrospun in high humidity conditions resulted in significantly increased mat thickness and decreased fiber diameters. The mats' alginate content was then isolated

Identifiers

PMID25530854
PMCPMC4269270
OpenAlexW2148246432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.