Evidence map›Paper›PMID 25530853›Full record

ArticleJournal of materials chemistry. B2014

Shape Transformation Following Reduction-Sensitive PEG Cleavage of Polymer/DNA Nanoparticles.

John-Michael Williford, Yong Ren, Kevin Huang, Deng Pan, Hai-Quan Mao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John-Michael WillifordDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205 ; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218 ; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
Yong RenDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218 ; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218 ; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
Kevin HuangDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218D.
Deng PanDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Hai-Quan MaoDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218 ; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218 ; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.

Funding

ValidationU54CA151838 · NCI · JOHNS HOPKINS UNIVERSITY · PI POMPER, MARTIN G · 2010 to 2014
$11.9M
Shape Control and Transfection of Self-assembled Polymer-DNA NanoparticlesR21EB013274 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MAO, HAI-QUAN · 2012 to 2013
$431k
NCI NIH HHS U54 CA151838NIBIB NIH HHS R21 EB013274
6 · The paper itself

Abstract

PEGylated polycation/DNA micellar nanoparticles have been developed that can undergo shape transformation upon cleavage of the PEG grafts in response to an environmental cue. As a proof-of-principle, DNA nanoparticles with higher PEG grafting density adopting long, worm- and rod-like morphologies, transition to more condensed nanoparticles with spherical and short-rod morphologies upon cleavage of a fraction of the PEG grafts from the copolymer. This shape transformation leads to increased surface charges, correlating with improved transfection efficiency.

Identifiers

PMID25530853
PMCPMC4269835

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.